Fig. 1

CYB5Aalt starts from novel TSS and CYB5Aalt is increased in relapse. A Comparison of RNAseq Read coverage (in RPKM log10) between CYB5Aalt positive and CYB5A WT samples reveals a novel TSS for CYB5Aalt and usage of two non-canonical exons upstream of CYB5A WT Exon 1 in representative patient samples (PL09 ID, PL09 REL). Arcs represent split reads between exons. Alternative Exon 2 skips CYB5A WT Exon 1 and splices into WT Exon 2. Exons of CYB5Aalt and CYB5A WT are illustrated beneath according to read coverage and genomic coordinates. B CYB5Aalt gene expression (in TPM log2) in matched ID-REL patient samples, which are CYB5Aalt positive. Colours represent matched patient samples. Connected dots represent matched expression values of patients at ID and REL