Fig. 3
From: SARS-CoV-2 and human retroelements: a case for molecular mimicry?
A. Mapping of the shared RE-CoV epitope “FNKDFY” to the SARS-CoV-2 RdRp (epitope in red), orange box depicting IgG antibody levels of severe vs. mild COVID-19 disease, with anti-FNKDFY antibodies showing 39-fold elevation in severe COVID-19. B. Mapping of the shared RE-CoV epitope “VKQIYK” to the SARS-CoV-2 spike protein (epitope in red), there are no reported significantly elevated antibodies against this epitope in severe COVID-19. C. Mapping of the shared RE-CoV epitope “TYICGF” to the SARS-CoV-2 2′-O-ribose methyltransferase (epitope in red), orange box depicting reported antibody levels of severe vs. mild COVID-19 disease, with anti-TYICGF antibodies showing a 4.6-fold elevation in severe COVID-19. D. Mapping of the shared RE-CoV epitope “ECFDKFKV” to the SARS-CoV-2 helicase (epitope in red). anti-ECFDKFKV antibodies showed a 2-fold elevation in severe COVID-19 E. Structure of a human LINE1 element with the coding regions for ORF1p (depicted in orange) and ORF2p (depicted in green)