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Table 3 The list of TF candidates which could bind to motif IV

From: MAGE genes encoding for embryonic development in cattle is mainly regulated by zinc finger transcription factor family and slightly by CpG Islands

TF family

Candidate transcription factors

Regulatory mode

Tissue expression

Zinc finger factors

SP1(Homo sapiens)

Dual

Testis and ovary

EGR1(Mus musculus)

Activation

Testis and ovary

KLF16(Homo sapiens)

Repression

Female gonad and testis

Bcl6b (Mus musculus)

Repression

Female gonad and testis

EGR3(Homo sapiens)

Activation

Ovary and testis

KLF1(Mus musculus)

Activation

Bone marrow and spleen

SP3(Homo sapiens)

Dual

Ovary and testis

KLF5(Homo sapiens)

Activation

Testis and placenta

SP2(Homo sapiens)

Activation

Testis and ovary

Znf423(Rattus norvegicus)

Dual

Brain, eye, spleen and heart

ESR2(Homo sapiens)

Activation

Testis and ovary

E2A-related factors

TCF4(Homo sapiens)

Activation

Testis, ovary and embryonic tissues expression mostly occurs in the brain

SMAD DNA binding factors

Smad3(Mus musculus)

Activation

brain and ovary

  1. SP1 Specificity protein 1, SP2 Specificity protein 2, SP3 Specificity protein 3, EGR1 Early growth response 1, EGR3 Early growth response 3, KLF16 Kruppel like factor 16, KLF1 Kruppel like factor 1, KLF5 Kruppel like factor 5, ESR2 Estrogen receptor beta, TCF4 Transcription factor 4, Znf423 Zinc finger protein 423, Smad3- fusion of Caenorhabditis elegans Sma genes and the Drosophila Mad, Mothers against decapentaplegic homolog 3, BCL6B B-cell lymphoma 6, member B *Statistical significance for the binding of given transcription factors to motif IV