Table 3 Disease association (DA) statistics for enhancers and transcription factors (TFs) within TADs in breast and prostate cancer. TADs are divided into two groups, containing no SNPs with a significant association to disease (control) and those containing at least one SNP with a significant disease association (SNP-rich). Statistics include the number of TADs used in the analysis, quantiles, and the inter-quantile range (IQR)
Statistic | Breast cancer | Prostate cancer | ||||||
|---|---|---|---|---|---|---|---|---|
Enhancer DA score | TF DA score | Enhancer DA score | Fraction of DA-TFsa | |||||
Control | SNP-rich | Control | SNP-rich | Control | SNP-rich | Control | SNP-rich | |
# of TADs | 16,473 | 26 | 10,463 | 17 | 13,587 | 291 | 10,070 | 241 |
1st quantile | 4.55 | 5.42 | 10.5 | 17.0 | 4.50 | 5.42 | 0.32 | 0.66 |
2nd quantile | 4.75 | 5.66 | 11.5 | 17.0 | 4.69 | 5.66 | 0.33 | 0.67 |
3rd quantile | 4.90 | 5.80 | 12.5 | 18.0 | 4.87 | 5.77 | 0.35 | 0.69 |
IQR | 0.35 | 0.38 | 2.0 | 1.0 | 0.37 | 0.35 | 0.03 | 0.03 |