Fig. 7
From: The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection
Indels. A. The mean mutation frequency for indels is plotted across the entire mtDNA genome. Frequencies were averaged if more than one mutation appeared in one base pair, Normalized values were found using {(x/max(x))}. Germline and somatic indel mutations in liver tissue of PolG mice for both B, mutation count, and C, mutation frequency. Total is the sum of germline and somatic indels. N = 14 for PolG, N = 3 for WT (wild type). D. Histogram of indel base pair changes. Negative values are deletions and positive values are insertions. Graph depicts all animals summed. Green bars represent bins summarizing multiple changes. Error bars are ±95% CI, black dots represent the median