Fig. 5

Mutation count, A., and Mutation frequency, B., for each type of base pair substitution. N = 14. Error bars are ±95% CI, black dots represent the median. Heatmap showing types of base pair substitutions in missense mutations and their effects on amino acid hydrophobicity for C., mutation count and D., mutation frequency. The reference amino acid state is on the left side and the resulting variant is across the top. The four most common types of mutations are presented here (see Supplementary Figs. S6, S7 for other types) (Additional File 1)). Redundant changes (e.g., C- > T and G- > A) are combined. Only missense mutations are included in the heatmap