Fig. 2

Germline (appearing in both tissues) and somatic (appearing only in one tissue) mutations in brain and liver tissue of PolG mice and liver tissue for wild type mice for both mutation count, A, and mutation frequency, B. Total is the sum of germline and somatic mutations. N = 14 for PolG, N = 3 for WT (wild type) liver, N = 2 for WT brain. PolG mice were between 9 and 12 months of age and WT mice were 9–10 weeks of age. Error bars are ±95% CI, black dots represent the median. *Because germline mutations are defined as being in both liver and brain tissue, tissue type cannot be separated for the mutation count metric, but it can be for the mutation frequency metric