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Table 4 Significant VIP variants and drug-related information in the Wa population

From: Genetic analysis of pharmacogenomic VIP variants in the Wa population from Yunnan Province of China

Variant PMID Molecules P-value #Of case #Of control Study size Bipgeographical group Paper discusses Gene
rs776746 16421475 tacrolimus   53   53 East Asian metabolism/PK CYP3A5
rs776746 23073468 tacrolimus 0.016 25   25 East Asian dosage CYP3A5
rs776746 21677300 tacrolimus 0.025 209   209 Mixed Population toxicity CYP3A5
rs776746 16424824 tacrolimus   201   201 East Asian metabolism/PK CYP3A5
rs776746 24120259 tacrolimus < 0.0001 68   68 East Asian metabolism/PK CYP3A5
rs4291 27546928 captopril 0.029 190   190 Unknown efficacy ACE
rs4291 18727619 aspirin 0.015 81 231 312 East Asian toxicity ACE
rs4291 20577119 amlodipinechlorthalidonelisinopril 0.0014 9309   9309 Mixed Population other ACE
rs3093105 20861217 vitamine < 0.003     Unknown metabolism/PK CYP4F2
rs1051298 19841321 bevacizumabpemetrexed 0.01 48   48 European efficacy SLC19A1
rs1051298 24732178 pemetrexed 0.016 136   136 Mixed Population efficacy SLC19A1
rs1065852 10223777 alpha-hydroxymetoprolol < 0.05 40   40 East Asian metabolism/PK CYP2D6
rs1065852 24528284 citalopramescitalopram 2.00E-16 435   435 European other CYP2D6
rs1065852 23277250 iloperidone 0.028 128   128 Unknown other CYP2D6
  1. p < 0.05 indicates statistical significance