Genetic analysis of pharmacogenomic VIP variants in the Wa population from Yunnan Province of China

BMC Genomic Data

Table 4 Significant VIP variants and drug-related information in the Wa population

Variant	PMID	Molecules	P-value	#Of case	#Of control	Study size	Bipgeographical group	Paper discusses	Gene
rs776746	16421475	tacrolimus		53		53	East Asian	metabolism/PK	CYP3A5
rs776746	23073468	tacrolimus	0.016	25		25	East Asian	dosage	CYP3A5
rs776746	21677300	tacrolimus	0.025	209		209	Mixed Population	toxicity	CYP3A5
rs776746	16424824	tacrolimus		201		201	East Asian	metabolism/PK	CYP3A5
rs776746	24120259	tacrolimus	< 0.0001	68		68	East Asian	metabolism/PK	CYP3A5
rs4291	27546928	captopril	0.029	190		190	Unknown	efficacy	ACE
rs4291	18727619	aspirin	0.015	81	231	312	East Asian	toxicity	ACE
rs4291	20577119	amlodipinechlorthalidonelisinopril	0.0014	9309		9309	Mixed Population	other	ACE
rs3093105	20861217	vitamine	< 0.003				Unknown	metabolism/PK	CYP4F2
rs1051298	19841321	bevacizumabpemetrexed	0.01	48		48	European	efficacy	SLC19A1
rs1051298	24732178	pemetrexed	0.016	136		136	Mixed Population	efficacy	SLC19A1
rs1065852	10223777	alpha-hydroxymetoprolol	< 0.05	40		40	East Asian	metabolism/PK	CYP2D6
rs1065852	24528284	citalopramescitalopram	2.00E-16	435		435	European	other	CYP2D6
rs1065852	23277250	iloperidone	0.028	128		128	Unknown	other	CYP2D6

ISSN: 2730-6844