Table 2 Virulence factors predicted in this non-toxigenic C. diphtheriae isolate
class | Virulence factors | Related genes | C. diphtheriae in this study | C. diphtheriae NCTC 13129 (biotype gravis) |
|---|---|---|---|---|
Adherence | SpaD-type pili | srtB | GE000724 | DIP0233 |
Surface-anchored pilus proteins | sapD | GE000470 | DIP0443 | |
Iron uptake | ABC transporter | fagA | GE000031; GE001029; GE001042; GE002284; GE003092 | DIP1061 |
fagB | GE000032; GE001030; GE002283; GE003093 | DIP1060 | ||
fagC | GE000033; GE001031; GE001044; GE002282 | DIP1059 | ||
fagD | GE000030; GE001032; GE002285; GE003091 | DIP1062 | ||
ABC-type heme transporter | hmuT | GE001688 | DIP0626 | |
hmuU | GE001689 | DIP0627 | ||
hmuV | GE001690 | DIP0628 | ||
Ciu iron uptake and siderophore biosynthesis system | ciuA | GE001639 | DIP0582 | |
ciuB | GE001640 | DIP0583 | ||
ciuC | GE001641 | DIP0584 | ||
ciuD | GE001642 | DIP0585 | ||
ciuE | GE001643 | DIP0586 | ||
Siderophore-dependent iron uptake system | irp6A | GE000857 | DIP0108 | |
irp6B | GE000856 | DIP0109 | ||
irp6C | GE000855 | DIP0110 | ||
Regulation | Diphtheria toxin repressor DtxR | dtxR | GE002692 | DIP1414 |
Sigma A (Mycobacterium) | sigA/rpoV | GE002685 | – | |
Sigma H (Mycobacterium) | sigH | GE000444 | – |