Table 2 Differentially expressed genes meeting the threshold of low false discovery rate (q < 0.05) and |log2 fold change| > 1
No. | GeneName | result | Transcript id | GeneID | MeanTPM (A) | MeanTPM (B) | log2FoldChange | pValue | qValue | GeneDescription | GO | KEGG | KOG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GALNS | up | ENSAMET00000000379 | ENSAMEG00000000312 | 41.27 | 18.8 | 1.134360776 | 0.0000000000000000092189 | 0.0000000000000027143580 | galactosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol;Acc:HGNC:4122] | GO:0070062;GO:0008484;GO:0008152;GO:0003824;GO:0043890 | – | KOG3867-Sulfatase [R] |
2 | NCF1 | down | ENSAMET00000016724 | ENSAMEG00000015198 | 1.536666667 | 268.47 | −7.448812824 | 0.0000000000000000000000 | 0.0000000000000000000000 | neutrophil cytosolic factor 1 [Source:HGNC Symbol;Acc:HGNC:7660] | GO:0016175;GO:0035091;GO:0055114;GO:0005737;GO:0017124;GO:0043325;GO:0006612;GO:0042554;GO:0005829;GO:0019898;GO:0043020;GO:0014068;GO:0034614;GO:0045741;GO:0045893;GO:0046330;GO:0071276;GO:1900745;GO:0005886 | – | – |
3 | GLG1 | down | ENSAMET00000001501 | ENSAMEG00000001334 | 0.283333333 | 14.76 | −5.703048571 | 0.0000000000000000000000 | 0.0000000000000000000000 | golgi glycoprotein 1 [Source:HGNC Symbol;Acc:HGNC:4316] | GO:0070062;GO:0016020;GO:0005794;GO:0000139;GO:0016021 | – | KOG3648-Golgi apparatus protein (cysteine-rich fibroblast growth factor receptor)[U] |
4 | C12orf56 | up | ENSAMET00000019892 | ENSAMEG00000018106 | 14.68666667 | 2.5 | 2.554506994 | 0.0000000000000000000000 | 0.0000000000000000000000 | chromosome 12 open reading frame 56 [Source:HGNC Symbol;Acc:HGNC:26967] | – | – | – |
5 | AZIN1 | down | ENSAMET00000016178 | ENSAMEG00000014703 | 25.47 | 61.03 | −1.260719631 | 0.0000000000000001900961 | 0.0000000000000502788186 | antizyme inhibitor 1 [Source:RefSeq peptide;Acc:NP_001278387] | GO:0006596;GO:0042978;GO:0043085;GO:0003824;GO:0042177;GO:1902269;GO:0005634 | – | KOG0622-Ornithine decarboxylase [E] |
6 | RCAN1 | down | ENSAMET00000005825 | ENSAMEG00000005295 | 0.0001 | 8.21 | −16.3250946 | 0.0000000000000165267939 | 0.0000000000036324030796 | regulator of calcineurin 1 [Source:HGNC Symbol;Acc:HGNC:3040] | GO:0033173;GO:0019722;GO:0003676;GO:0005622 | K17901-ko04921 Oxytocin signaling pathway;ko04919 Thyroid hormone signaling pathway | KOG4019-Calcineurin-mediated signaling pathway inhibitor DSCR1[TR] |
7 | RASD1 | up | ENSAMET00000002517 | ENSAMEG00000002311 | 15.45333333 | 0.76 | 4.345774837 | 0.0000000000025012050313 | 0.0000000003903130451290 | ras related dexamethasone induced 1 [Source:HGNC Symbol;Acc:HGNC:15828] | GO:0016529;GO:0003924;GO:0005525;GO:0000166;GO:0007165;GO:0016020 | – | KOG0395-Ras-related GTPase [R] |
8 | CYSLTR1 | up | ENSAMET00000021716 | ENSAMEG00000019893 | 19.67666667 | 8.01 | 1.296611693 | 0.0000000000033418073494 | 0.0000000005112637616410 | cysteinyl leukotriene receptor 1 [Source:HGNC Symbol;Acc:HGNC:17451] | GO:0004974;GO:0061737;GO:0007186;GO:0004930;GO:0016021;GO:0016020;GO:0002437;GO:0006816;GO:0006935;GO:0007166;GO:0005887 | K04322-ko04020 Calcium signaling pathway;ko04080 Neuroactive ligand-receptor interaction | – |
9 | EGR1 | up | ENSAMET00000018184 | ENSAMEG00000016544 | 63.94333333 | 4.81 | 3.732685154 | 0.0000000000130159154540 | 0.0000000017816961461400 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | GO:0005737;GO:0005654;GO:0005634;GO:2000182;GO:0098759;GO:0090090;GO:0071480;GO:0071310;GO:0070498;GO:0061418;GO:0050725;GO:0046886;GO:0045944;GO:0045893;GO:0045080;GO:0044849;GO:0042981;GO:0035914;GO:0033233;GO:0032868;GO:0030509;GO:0030217;GO:0009749;GO:0006366;GO:0006355;GO:0002931;GO:0001666;GO:0000122;GO:1990841;GO:0044212;GO:0044729;GO:0043565;GO:0035035;GO:0010385;GO:0008270;GO:0003700;GO:0003677;GO:0001077;GO:0000982;GO:0000977;GO:0000976;GO:0006351;GO:0003676;GO:0046872 | K09203-ko05020 Prion diseases;ko04933 AGE-RAGE signaling pathway in diabetic complications;ko05166 HTLV-I infection | KOG1721-FOG: Zn-finger [R] |
10 | RANBP9 | up | ENSAMET00000000514 | ENSAMEG00000000415 | 8.37 | 1.31 | 2.675660811 | 0.0000000000223677291954 | 0.0000000029087367841100 | RAN binding protein 9 [Source:HGNC Symbol;Acc:HGNC:13727] | GO:0005737;GO:0005634;GO:0070373;GO:0019899 | – | KOG1477-SPRY domain-containing proteins [R] |
11 | UCHL1 | down | ENSAMET00000018946 | ENSAMEG00000017217 | 2.423333333 | 8.48 | − 1.807071401 | 0.0000000003728989939510 | 0.0000000401316469007000 | ubiquitin C-terminal hydrolase L1 [Source:HGNC Symbol;Acc:HGNC:12513] | GO:0006511;GO:1904115;GO:0016874;GO:0016787;GO:0016579;GO:0006508;GO:0036459;GO:0008234;GO:0008233;GO:0004843;GO:0005622;GO:0004197;GO:0008242;GO:0031625;GO:0031694;GO:0043130;GO:0043407;GO:0005654;GO:0005737;GO:0005829;GO:0005886;GO:0070062 | – | KOG1415-Ubiquitin C-terminal hydrolase UCHL1[O] |
12 | TNFSF12 | up | ENSAMET00000018386 | ENSAMEG00000016729 | 8.51 | 0.0001 | 16.37687151 | 0.0000000004630328987080 | 0.0000000481708558955999 | TNF superfamily member 12 [Source:HGNC Symbol;Acc:HGNC:11927] | GO:0005164;GO:0006955;GO:0016020;GO:0045732;GO:0097191;GO:2001238;GO:0005576;GO:0048471 | – | – |
13 | SERPINB10 | up | ENSAMET00000016640 | ENSAMEG00000015156 | 58.52 | 13.83 | 2.081128613 | 0.0000000032653933058800 | 0.0000002715024303890000 | serpin family B member 10 [Source:HGNC Symbol;Acc:HGNC:8942] | GO:0005615;GO:0005634;GO:0005829 | – | KOG2392-Serpin [V] |
14 | SPPL2B | up | ENSAMET00000006059 | ENSAMEG00000005486 | 65.44666667 | 26.61 | 1.298351204 | 0.0000000042149703973800 | 0.0000003425761096409990 | signal peptide peptidase like 2B [Source:HGNC Symbol;Acc:HGNC:30627] | GO:0071556;GO:0030660;GO:0071458;GO:0016020;GO:0015629;GO:0010008;GO:0005886;GO:0005813;GO:0005765;GO:0005654;GO:0050776;GO:0033619;GO:0031293;GO:0006509;GO:0042803;GO:0042500;GO:0004190;GO:0016021 | – | KOG2442-Uncharacterized conserved protein, contains PA domain [R] |
15 | PTP4A3 | up | ENSAMET00000001697 | ENSAMEG00000001550 | 38.58666667 | 5.66 | 2.769228463 | 0.0000000599264476394000 | 0.0000035422432402000000 | protein tyrosine phosphatase type IVA, member 3 [Source:HGNC Symbol;Acc:HGNC:9636] | GO:1900746;GO:0043542;GO:0043117;GO:0007219;GO:0006470;GO:0016311;GO:0016791;GO:0008138;GO:0006355;GO:1901224;GO:1904951;GO:0005634;GO:0005737;GO:1990830 | – | KOG2836-Protein tyrosine phosphatase IVA1[T] |
16 | FOS | up | ENSAMET00000020143 | ENSAMEG00000018335 | 1639.143333 | 71.19 | 4.525123604 | 0.0000011001521433000000 | 0.0000455381278412000000 | Fos proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3796] | GO:0005654;GO:0005667;GO:0005634;GO:0071277;GO:0060395;GO:0045944;GO:0045893;GO:0045672;GO:0042493;GO:0035994;GO:0035914;GO:0034614;GO:0031668;GO:0007399;GO:0007179;GO:0006355;GO:0070412;GO:0044212;GO:0008134;GO:0003700;GO:0003682;GO:0003677;GO:0001077;GO:0000979;GO:0000978;GO:0006357;GO:0006366;GO:0001102;GO:0001190;GO:0046982;GO:0071276;GO:0032993;GO:0035976 | K04379-ko04010 MAPK signaling pathway;ko04668 TNF signaling pathway;ko04024 cAMP signaling pathway;ko04210 Apoptosis;ko04620 Toll-like receptor signaling pathway;ko04660 T cell receptor signaling pathway;ko04662 B cell receptor signaling pathway;ko04915 Estrogen signaling pathway;ko04917 Prolactin signaling pathway;ko04921 Oxytocin signaling pathway;ko04725 Cholinergic synapse;ko04728 Dopaminergic synapse;ko04380 Osteoclast differentiation;ko04713 Circadian entrainment;ko05200 Pathways in cancer;ko05231 Choline metabolism in cancer;ko05210 Colorectal cancer;ko05224 Breast cancer;ko05323 Rheumatoid arthritis;ko05031 Amphetamine addiction;ko05132 Salmonella infection;ko05133 Pertussis;ko05166 HTLV-I infection;ko05161 Hepatitis B;ko05168 Herpes simplex infection;ko05140 Leishmaniasis;ko05142 Chagas disease (American trypanosomiasis);ko01522 Endocrine resistance | KOG1414-Transcriptional activator FOSB/c-Fos and related bZIP transcription factors [K] |
17 | ARHGAP21 | up | ENSAMET00000007161 | ENSAMEG00000006453 | 5.533333333 | 2.03 | 1.446669108 | 0.0000060927451965700000 | 0.000197666 | Rho GTPase activating protein 21 [Source:HGNC Symbol;Acc:HGNC:23725] | GO:0005096;GO:0043547;GO:0007165;GO:0030054;GO:0015629;GO:0005886;GO:0005794;GO:0072384;GO:0051684;GO:0051683;GO:0007030 | – | – |
18 | FOSB | up | ENSAMET00000013608 | ENSAMEG00000012405 | 204.76 | 6.83 | 4.905904523 | 0.0000086438020328300000 | 0.000266574 | FosB proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3797] | GO:0043231;GO:0005654;GO:0071277;GO:0045944;GO:0003677;GO:0001077;GO:0000978;GO:0006357;GO:0005634;GO:0003700;GO:0006366;GO:0006355 | K09029-ko04380 Osteoclast differentiation;ko05030 Cocaine addiction;ko05031 Amphetamine addiction;ko05034 Alcoholism | KOG1414-Transcriptional activator FOSB/c-Fos and related bZIP transcription factors [K] |
19 | IFI27L2 | up | ENSAMET00000006889 | ENSAMEG00000006288 | 798.83 | 337.07 | 1.244840284 | 0.0000096178956521000000 | 0.000292568 | interferon alpha inducible protein 27 like 2 [Source:HGNC Symbol;Acc:HGNC:19753] | GO:0016021;GO:0016020 | – | – |
20 | ANXA3 | down | ENSAMET00000005999 | ENSAMEG00000005375 | 13.09666667 | 44.12 | −1.752233124 | 0.0000856456143253000000 | 0.001808525 | annexin A3 [Source:HGNC Symbol;Acc:HGNC:541] | GO:0070062;GO:0042581;GO:0030670;GO:0016020;GO:0005829;GO:0005886;GO:0005737;GO:0051091;GO:0045766;GO:0043312;GO:0042742;GO:0006909;GO:0010595;GO:0048306;GO:0005544;GO:0004859;GO:0043086;GO:0005509 | – | KOG0819-Annexin [U] |
21 | CLIC4 | up | ENSAMET00000011061 | ENSAMEG00000010080 | 14.94333333 | 6.36 | 1.232403328 | 0.000125571 | 0.002467927 | chloride intracellular channel 4 [Source:HGNC Symbol;Acc:HGNC:13518] | GO:0070062;GO:0048471;GO:0045177;GO:0030496;GO:0016363;GO:0015630;GO:0009986;GO:0005911;GO:0005886;GO:0005902;GO:0005829;GO:0005739;GO:0005813;GO:0005737;GO:0005622;GO:0071277;GO:0061299;GO:0048754;GO:0035264;GO:0030336;GO:0030216;GO:0009566;GO:0007035;GO:0001886;GO:0001525;GO:0034707;GO:0005254;GO:0006821;GO:1902476;GO:0034765;GO:0005244;GO:0006811;GO:0006810;GO:0016020 | – | KOG1422-Intracellular Cl- channel CLIC, contains GST domain [P] |
22 | COL2A1 | up | ENSAMET00000014144 | ENSAMEG00000012885 | 15.23 | 6.57 | 1.212950666 | 0.000132805 | 0.002568066 | collagen type II alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2200] | GO:0005669;GO:0006352;GO:0046982;GO:0003700;GO:0006355;GO:0000118;GO:0016575;GO:0032041;GO:0004407;GO:0070932;GO:0016569;GO:0006325;GO:0006351;GO:0005634;GO:0016787;GO:0031012;GO:0005585;GO:0060272;GO:0030199;GO:0007605;GO:0007601;GO:0001501;GO:0048407;GO:0005201;GO:0042289;GO:0005576 | – | KOG3544-Collagens (type IV and type XIII), and related proteins [W] |
23 | DUSP22 | up | ENSAMET00000006552 | ENSAMEG00000005967 | 41.65333333 | 15.57 | 1.419663008 | 0.00020624 | 0.003683723 | dual specificity phosphatase 22 [Source:HGNC Symbol;Acc:HGNC:16077] | GO:0000122;GO:0035335;GO:0016311;GO:0016791;GO:0008138;GO:0006470 | – | KOG1716-Dual specificity phosphatase [V] |
24 | EPCAM | down | ENSAMET00000006851 | ENSAMEG00000006223 | 2.763333333 | 5.91 | −1.096748529 | 0.000258111 | 0.004446881 | epithelial cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:11529] | GO:0070062;GO:0016328;GO:0016323;GO:0016324;GO:0009986;GO:0005923;GO:0005886;GO:2000648;GO:2000048;GO:0048863;GO:0045944;GO:0023019;GO:0008284;GO:0001657;GO:0032403;GO:0016020;GO:0016021 | – | – |
25 | PDE4A | up | ENSAMET00000012636 | ENSAMEG00000011455 | 6.78 | 2.24 | 1.597786541 | 0.000451773 | 0.006951735 | phosphodiesterase 4A [Source:HGNC Symbol;Acc:HGNC:8780] | GO:0004114;GO:0008081;GO:0016787;GO:0007165;GO:0046872;GO:0048471;GO:0016020;GO:0005886;GO:0005737;GO:0005829;GO:0005654;GO:0043949;GO:0035690;GO:0010738;GO:0007608;GO:0006198;GO:0030552;GO:0004115 | – | KOG3689-Cyclic nucleotide phosphodiesterase [T] |
26 | MYBL1 | down | ENSAMET00000013645 | ENSAMEG00000012401 | 4.073333333 | 15.41 | −1.919585077 | 0.000777204 | 0.010437403 | MYB proto-oncogene like 1 [Source:HGNC Symbol;Acc:HGNC:7547] | GO:0045944;GO:0001077;GO:0000978;GO:0006366;GO:0006355;GO:0003677 | – | KOG0048-Transcription factor, Myb superfamily [K] |
27 | STEAP3 | up | ENSAMET00000009325 | ENSAMEG00000008497 | 18.19 | 6.95 | 1.38806066 | 0.000805245 | 0.010721711 | STEAP3 metalloreductase [Source:HGNC Symbol;Acc:HGNC:24592] | GO:0005771;GO:0005737;GO:0009306;GO:0016020;GO:0016021 | – | – |
28 | UNC119 | up | ENSAMET00000005420 | ENSAMEG00000004930 | 111.16 | 50.33 | 1.143147237 | 0.002244887 | 0.022926346 | unc-119 lipid binding chaperone [Source:HGNC Symbol;Acc:HGNC:12565] | GO:0051233;GO:0045171;GO:0005813;GO:0000922;GO:0061098;GO:0042953;GO:0008289;GO:0007399;GO:0000281 | – | KOG4037-Photoreceptor synaptic vesicle protein HRG4/UNC-119[UT] |
29 | ENG | up | ENSAMET00000016623 | ENSAMEG00000015119 | 36.99666667 | 8.75 | 2.08004037 | 0.003054818 | 0.028699842 | endoglin [Source:HGNC Symbol;Acc:HGNC:3349] | GO:0007165;GO:0016020;GO:0016021;GO:0005072;GO:0005114;GO:0005534;GO:0005539;GO:0034713;GO:0036122;GO:0042803;GO:0050431;GO:0001300;GO:0001525;GO:0001569;GO:0001570;GO:0001934;GO:0001947;GO:0003148;GO:0003198;GO:0003203;GO:0003208;GO:0003209;GO:0003222;GO:0003273;GO:0006355;GO:0007507;GO:0010629;GO:0010862;GO:0017015;GO:0022009;GO:0030336;GO:0030513;GO:0031953;GO:0035912;GO:0045766;GO:0045944;GO:0048745;GO:0048844;GO:0048845;GO:0055009;GO:0097084;GO:1905007;GO:1905065;GO:1905222;GO:0005615;GO:0005925;GO:0009897;GO:0043235;GO:0072563 | – | – |