Fig. 3

Regional plots for the associations in regions surrounding the rs2846071 or rs4149577 in the discovery stage. Genomic positions are based on NCBI Build 37. In the meta-analysis, the P value of the SNP is shown as purple diamonds, with their initial P value in the discovery stage shown as purple dots. The linkage disequilibrium (LD) values (r²) to rs2846071 or rs4149577 for the other SNPs are indicated by marked color. Red signifies r² > 0.8, orange 0.6 < r² ≤ 0.8, green 0.4 < r² ≤ 0.6, light blue 0.2 < r² ≤ 0.4 and blue r² ≤ 0.2. Estimated recombination rates, which are derived from the East Asian populations of the 1000 Genomes Project (phase 3), are plotted in blue. Genes within the 500 kb region surrounding the index SNPs rs2846071 (a) or rs4149577 (b) are annotated, with the positions of transcripts shown by arrows. The East Asian populations from the 1000 Genomes Project consist of 504 subjects from the CHB (Han Chinese in Beijing, China), CHS (Southern Han Chinese), CDX (Chinese Dai in Xishuangbanna, China), JPT (Japanese in Tokyo, Japan) and KHV (Kinh in Ho Chi Minh City, Vietnam)