Fig. 2

Manhattan plot and Quantile-quantile plot of the genome-wide P values from the association test on tinnitus. a The Manhattan plot of genome-wide P values for the genotyped and imputed SNPs using logistic regression analyses in the cases/controls population in the discovery stage under the additive model. The x-axis represents the genomic position (based on NCBI Build 37), and the y-axis shows the -log10 (P). b The quantile-quantile plot. The red line represents the null hypothesis of no true association. The black line with gradient λ (inflation coefficient) is fitted to the lower 90% of the distribution of the observed test statistics. The plot is based on the genotyped and imputed SNPs that passed the quality controls. The value of the inflation factor λ is 1.003 under the additive model