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Table 3 Mendelian Randomization for the causal effect of CpG sites on CHD risk

From: Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease

CpG CHR POSITION Nearby Gene mQTL SNPa POSITION p.MR1b p.MR2c
cg00598125 6 32,555,411 HLA-DRB1 kgp10246631 32,504,218 0.53 3.27e-05
kgp3830872 32,519,391   
kgp11968335 32,554,197   
kgp12271317 32,561,327   
rs9270894 32,571,872   
kgp132887 32,578,970   
kgp7143578 32,589,959   
  1. a 7 mQTL SNPs of cg00598125 were used as instrumental SNPs in Mendelian randomization
  2. b MR analysis in CHD GWAS Phase 1
  3. c MR analysis in CHD GWAS Phase 2