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Table 3 Mendelian Randomization for the causal effect of CpG sites on CHD risk

From: Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease

CpG

CHR

POSITION

Nearby Gene

mQTL SNPa

POSITION

p.MR1b

p.MR2c

cg00598125

6

32,555,411

HLA-DRB1

kgp10246631

32,504,218

0.53

3.27e-05

kgp3830872

32,519,391

  

kgp11968335

32,554,197

  

kgp12271317

32,561,327

  

rs9270894

32,571,872

  

kgp132887

32,578,970

  

kgp7143578

32,589,959

  
  1. a 7 mQTL SNPs of cg00598125 were used as instrumental SNPs in Mendelian randomization
  2. b MR analysis in CHD GWAS Phase 1
  3. c MR analysis in CHD GWAS Phase 2
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BMC Genomic Data

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