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Table 2 Co-localization analysis with two CHD GWASs and eQTL findings

From: Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease

Chro Regions Gene Source for Co-localization PP0 PP1 PP2 PP3 PP4
6 32,520,489–32,527,779 HLA-DRB6 GWAS – Phase 1 1.12e-10 0.028 1.95e-09 0 0.972
10 93,542,595–93,558,048 TNKS2-AS1 eQTL – Artery Aorta 1.11e-02 2.11e-02 5.07e-04 0 0.967
eQTL – Artery Tibial 2.12e-03 4.04e-03 5.21e-04   0.993
eQTL – Heart Atrial Appendage 1.34e-04 2.56e-04 5.24e-04   0.999
eQTL – Heart Left Ventricle 8.05e-04 1.53e-03 5.23e-04   0.997
14 77,425,980–77,432,145 LINC01629 eQTL – Artery Aorta 3.70e-03 2.95e-02 1.97e-04 6.04e-04 0.966
eQTL – Artery Tibial 1.38e-07 1.09e-06 1.27e-04 0 0.999
eQTL – Heart Artial Appendage 3.11e-06 2.45e-05 1.27e-04 0 0.999
5 33,440,801–33,468,196 TARS eQTL – Artery Aorta 2.72E-07 1.37e-02 1.95e-08 0 0.986
eQTL – Artery Tibial 2.41E-08 1.22e-03 1.97e-08 0 0.999
19 37,803,738–37,855,358 ZNF875 eQTL – Heart Artial Appendage 1.93e-05 5.59e-07 3.34e-02 0 0.967
eQTL – Heart Left Ventricle 2.42e-05 7.01e-07 3.34e-02 0 0;967
19 53,362,743–53,400,947 ZNF320 eQTL – Artery Aorta 1.03e-12 2.85e-03 3.50e-14 0 0.972
eQTL – Artery Tibial 6.95e-13 1.93e-03 3.53e-14 0 0.981
10 104,613,966–104,661,655 BORCS7 / ASMT eQTL – Artery Aorta 1.10e-02 6.92e-04 1.55e-02 5.11e-06 0.973
eQTL – Artery Tibial 7.95e-05 5.00e-06 1.57e-02 0 0.984
  1. PP0 – PP4: Bayesian posterior probability for hypotheses H0 to H4, respectively
  2. H0: there exist no causal variants for either trait;
  3. H1: there exists a causal variant for trait 1;
  4. H2: there exists a causal variant for trait 2;
  5. H3: there exist two distinct causal variants, one for each trait; or
  6. H4: there exists a single causal variant common to both traits
  7. HLA-DRB6: major histocompatibility complex, class II, DR beta 6
  8. TNKS2-AS1: TNKS2 antisense RNA 1
  9. LINC01629: long intergenic non-protein coding RNA 1629
  10. TARS: threonyl-tRNA synthetase
  11. ZNF875: Homo sapiens zinc finger protein 875
  12. ZNF320: zinc finger protein 320
  13. BORCS7 / ASMT: BLOC-1 related complex subunit 7 / acetylserotonin O- methyltransferase