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Table 1 Twenty SNPs in neuropeptide genes that are highly differentiated between Africans and non-Africans

From: Selected neuropeptide genes show genetic differentiation between Africans and non-Africans

SNP ID

Chromosome

HGNC Symbol

Ref

Ancestor

Derived

ΔDAF |(African - non-African)|

Feature keya (Position)

FST YRI vs CEU

FST YRI vs CHB

eQTL (↓decrease; ↑increase)

rs3842753

11

INS

T

T

G

0.50

 

0.44

0.70

TH↑; IGF2-AS↓; IGF2↑

rs3847193

9

QRFP

G

A

G

0.42

Propeptide (19–90)

0.34

0.68

QRFP↓; FIBCD1↑

rs2291725

17

GIP

T

T

C

0.38

Propeptide (95–153)

0.49

0.64

AC091133.1↓; ATP5G1↑; ATP5G1↓; CDK5RAP3↑; HOXB-AS1↑; HOXB2↑; SNF8↑; SUMO2P17↑; TTLL6↓; UBE2Z↑; UBE2Z↓

rs699

1

AGT

A

G

A

0.36

 

0.46

0.07

AGT↑; AGT↓; COG2↑

rs6788319

3

UTS2B

C

T

A

0.34

Signal peptide (1–28)

0.27

0.22

UTS2B↓; UTS2B↑; CCDC50↓; OSTN-AS1↑

rs10770125

11

IGF2

A

A

G

0.32

 

0.30

0.21

IGF2-AS↓

rs5065

1

NPPA

A

G

A

0.30

 

0.16

0.42

CLCN6↑; MTHFR↑; NPPA↑; NPPA-AS1↑

rs2286472

16

NPW

A

C

A

0.29

Propeptide (65–165)

0.17

0.18

NPW↓; RP11-304 L19.13↑; SLC9A3R2↑; SYNGR3↑

rs1885137

14

SERPINA11

T

T

G

0.28

 

0.36

0.09

RP11-349I1.2↓; SERPINA11↓

rs7121

20

GNAS

C

T

C

0.28

 

0.35

0.12

GNAS↑; CTSZ↑

rs757081

11

NUCB2

C

C

G

0.26

 

0.39

0.40

RP1-239B22.5↓; PIK3C2A↓; OR7E14P↓; NUCB2↓; NCR3LG1↓; KCNJ11↓

rs990310

10

NPS

C

C

T

0.24

Signal peptide (1–23)

0.30

0.32

 

rs742711

20

CHGB

G

G

A

0.21

 

0.13

0.19

KANK1P1↑; CHGB↑

rs236152

20

CHGB

C

C

G

0.21

 

0.13

0.02

CHGB↑; KANK1P1↑; LRRN4↓; MCM8↓; RP5-1056H1.2↑

rs6085324

20

CHGB

T

T

A

0.21

 

0.13

0.19

KANK1P1↑; CHGB↑;

rs1799917

16

GNAO1

A

G

A

0.21

 

0.10

0.28

AMFR↑; AMFR↓; BBS2↑; RP11-413H22.3↓

rs236150

20

CHGB

G

G

C

0.21

O-glycosylated (116–120)

0.22

0.22

 

rs34123523

16

AGRP

C

C

T

0.21

Propeptide (21–82)

0.16

0.21

 

rs1058046

17

PYY

G

G

C

0.20

Propeptide (68–97)

0.11

0.05

PYY↓

rs742710

20

CHGB

C

C

T

0.20

 

0.21

0.02

 
  1. aFeature key refer to the Post-translational modifications (PTM) events in the protein and position refer to the PTM events position in the protein
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BMC Genomic Data

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