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Table 1 Twenty SNPs in neuropeptide genes that are highly differentiated between Africans and non-Africans

From: Selected neuropeptide genes show genetic differentiation between Africans and non-Africans

SNP ID Chromosome HGNC Symbol Ref Ancestor Derived ΔDAF |(African - non-African)| Feature keya (Position) FST YRI vs CEU FST YRI vs CHB eQTL (↓decrease; ↑increase)
rs3842753 11 INS T T G 0.50   0.44 0.70 TH↑; IGF2-AS↓; IGF2↑
rs3847193 9 QRFP G A G 0.42 Propeptide (19–90) 0.34 0.68 QRFP↓; FIBCD1↑
rs2291725 17 GIP T T C 0.38 Propeptide (95–153) 0.49 0.64 AC091133.1↓; ATP5G1↑; ATP5G1↓; CDK5RAP3↑; HOXB-AS1↑; HOXB2↑; SNF8↑; SUMO2P17↑; TTLL6↓; UBE2Z↑; UBE2Z↓
rs699 1 AGT A G A 0.36   0.46 0.07 AGT↑; AGT↓; COG2↑
rs6788319 3 UTS2B C T A 0.34 Signal peptide (1–28) 0.27 0.22 UTS2B↓; UTS2B↑; CCDC50↓; OSTN-AS1↑
rs10770125 11 IGF2 A A G 0.32   0.30 0.21 IGF2-AS↓
rs5065 1 NPPA A G A 0.30   0.16 0.42 CLCN6↑; MTHFR↑; NPPA↑; NPPA-AS1↑
rs2286472 16 NPW A C A 0.29 Propeptide (65–165) 0.17 0.18 NPW↓; RP11-304 L19.13↑; SLC9A3R2↑; SYNGR3↑
rs1885137 14 SERPINA11 T T G 0.28   0.36 0.09 RP11-349I1.2↓; SERPINA11↓
rs7121 20 GNAS C T C 0.28   0.35 0.12 GNAS↑; CTSZ↑
rs757081 11 NUCB2 C C G 0.26   0.39 0.40 RP1-239B22.5↓; PIK3C2A↓; OR7E14P↓; NUCB2↓; NCR3LG1↓; KCNJ11↓
rs990310 10 NPS C C T 0.24 Signal peptide (1–23) 0.30 0.32  
rs742711 20 CHGB G G A 0.21   0.13 0.19 KANK1P1↑; CHGB↑
rs236152 20 CHGB C C G 0.21   0.13 0.02 CHGB↑; KANK1P1↑; LRRN4↓; MCM8↓; RP5-1056H1.2↑
rs6085324 20 CHGB T T A 0.21   0.13 0.19 KANK1P1↑; CHGB↑;
rs1799917 16 GNAO1 A G A 0.21   0.10 0.28 AMFR↑; AMFR↓; BBS2↑; RP11-413H22.3↓
rs236150 20 CHGB G G C 0.21 O-glycosylated (116–120) 0.22 0.22  
rs34123523 16 AGRP C C T 0.21 Propeptide (21–82) 0.16 0.21  
rs1058046 17 PYY G G C 0.20 Propeptide (68–97) 0.11 0.05 PYY↓
rs742710 20 CHGB C C T 0.20   0.21 0.02  
  1. aFeature key refer to the Post-translational modifications (PTM) events in the protein and position refer to the PTM events position in the protein