Table 4 Signatures of polygenic adaptation through functional enrichment analysis. We have listed the most relevant terms of the analysis. The two lists of genes used for the analysis were taken from the significant windows under putative positive selection for SFselect and iHS. The genes used for this analysis are listing the genes with significant SFselect or iHS scores. A biological term was considered significant if the p-value after a Benjamini-Hochbert (BH) correction was below an alpha value of 0.05
From: Positive selection in admixed populations from Ethiopia
Term | Population | P-value (BH) | Test |
|---|---|---|---|
Response to virus | Amhara | 0.006 | SFselect |
RNA surveillance | Somali | 0.005 | SFselect |
Regulation of viral process | Wolayta | 0.026 | SFselect |
Type I interferon binding | Amhara | 0.018 | SFselect |
Type I interferon production | Gumuz | 0.020 | SFselect |
Positive regulation of interferon-gamma production | Gumuz | 0.027 | iHS |
B-cell activation and regulation of immunoglobulin production | Amhara, Somali | 0.017; 0.01 | SFselect |
Regulation of immunoglobulin production | Amhara | 0.018 | SFselect |
Hepatitis B | Amhara | 0.03 | SFselect |
Tuberculosis | Amhara | 0.047 | SFselect |
Measles | Amhara | 0.04 | SFselect |
Leishmaniasis | Gumuz | 0.049 | iHS |
Lupus erythematous | Somali, Wolayta, Gumuz | 0.0009; 0.02; 0.026 | iHS |
Folic acid containing compound metabolic process | Amhara, Somali, Wolayta | 0.013; 0.02; 0.02 | SFselect |
Folic acid metabolic process | Amhara, Wolayta | 0.019; 0.01 | SFselect |
Metabolism of folate | Amhara | 0.017 | SFselect |
Pterines and folate biosynthesis | Amhara | 0.02 | SFselect |
Cellular response to UV-B | Amhara, Somali | 0.002; 0.0019 | SFselect |
Cellular response to UV | Amhara, Somali | 0.018; 0.0027 | SFselect |
Cellular response to radiation | Amhara, Somali | 0.01; 0.001 | SFselect |
Cellular response to vitamin D | Amhara | 0.02 | SFselect |
Bone mineralization | Somali | 0.03 | SFselect |
Osteoclast differentiation | Wolayta | 0.03 | SFselect |
Negative regulation of cardiac muscle tissue development | Gumuz | 0.02 | SFselect |
Negative regulation of striated muscle tissue development | Gumuz | 0.037 | SFselect |
Muscle fibre development | Somali | 0.036 | iHS |