Table 3 Top 10 GO terms of biological processes and significant KEGG pathways of upregulated and downregulated DEGs for EC tissues compared with NE tissues
From: Bioinformatic screening for candidate biomarkers and their prognostic values in endometrial cancer
Term | Description | Count | P-Value | FDR |
|---|---|---|---|---|
Upregulated DEGs | ||||
 GO:0022403 | cell cycle phase | 47 | 1.16E-30 | 1.93E-27 |
 GO:0000279 | M phase | 42 | 2.96E-29 | 4.94E-26 |
 GO:0000278 | mitotic cell cycle | 42 | 3.27E-27 | 5.44E-24 |
 GO:0000280 | nuclear division | 34 | 3.43E-26 | 5.71E-23 |
 GO:0007067 | mitosis | 34 | 3.43E-26 | 5.71E-23 |
 GO:0000087 | M phase of mitotic cell cycle | 34 | 6.25E-26 | 1.04E-22 |
 GO:0022402 | cell cycle process | 48 | 9.63E-26 | 1.60E-22 |
 GO:0048285 | organelle fission | 34 | 1.30E-25 | 2.16E-22 |
 GO:0007049 | cell cycle | 53 | 3.71E-24 | 6.18E-21 |
 GO:0051301 | cell division | 33 | 5.63E-21 | 9.38E-18 |
KEGG pathway | ||||
 hsa04110 | Cell cycle | 18 | 1.70E-11 | 1.87E-08 |
 hsa04914 | Progesterone-mediated oocyte maturation | 10 | 1.30E-05 | 1.42E-02 |
 hsa04114 | oocyte meiosis | 11 | 1.48E-05 | 1.62E-02 |
Downregulated DEGs | ||||
 GO:0001501 | skeletal system development | 21 | 2.58E-07 | 4.35E-04 |
 GO:0001944 | vasculature development | 16 | 1.53E-05 | 2.57E-02 |
 GO:0007155 | cell adhesion | 28 | 2.67E-05 | 4.50E-02 |
 GO:0022610 | biological adhesion | 28 | 2.74E-05 | 4.61E-02 |