Table 1 Candidate SNP markers of male reproductive potential in the human Y-linked protein-coding genes and their comparison with the genome-wide patterns
Data: GRCh38, dbSNP rel. 151 [8] | Result | H0: neutral natural selection | H0: ↑♂ and ↓♂ sameness | ||||||
|---|---|---|---|---|---|---|---|---|---|
Human body systems | NGENE | NSNP | NRES | N> | N< | P(N<≡4 N> ≡ 4NRES/5) | N↑ | N↓ | P(N↑ ≡ N↓ ≡ NRES/2) |
Whole-genome norm for SNPs within TF-sites [42] | 104 | 105 | 1000 | 200 | 800 | > 0.52 | |||
Clinical SNP markers for diseases in TBP-sites [31] | 33 | 203 | 51 | 14 | 37 | > 0.93 | |||
Candidate SNP markers mainly for female reproductive potential in TBP-sites [40] | 22 | 129 | 24 | 19 | 5 | < 0.000001 | |||
Y-linked genes@ in PAR1 (pseudo-autosomal region 1) | 15 | 899 | 211 | 143 | 68 | < 0.000001 | 101 | 110 | > 0.2 |
Y-linked genes in PAR2 (pseudo-autosomal region 2) | 3 | 135 | 25 | 20 | 5 | < 0.000001 | 10 | 15 | > 0.1 |
Male-specific Y-linked genes@ paralogous to the appropriate X-linked genes | 8 | 56 | 13 | 8 | 5 | < 0.01 | 4 | 9 | > 0.1 |
Male-specific Y-linked unique genes@ | 6 | 41 | 12 | 6 | 6 | < 0.025 | 4 | 8 | > 0.1 |
Y-linked protein-coding genes@ | 32 | 1131 | 261 | 176 | 85 | < 0.000001 | 119 | 142 | > 0.06 |
Other Y-linked protein-coding genes in humans | 31 | 75 | – | – | – | – | – | – | |
TOTAL | 63 | 1206 | 261 | 176 | 85 | < 0.000001 | 119 | 142 | > 0.06 |