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Fig. 4 | BMC Genetics

Fig. 4

From: Disruptive natural selection by male reproductive potential prevents underexpression of protein-coding genes on the human Y chromosome as a self-domestication syndrome

Fig. 4

The significant correlations between the in silico predicted and in vitro experimentally measured values. a TBP–DNA affinity and b the TBP–DNA affinity change caused by the minor allele of the analyzed SNPs with respect to the norm, −ln [KD] and Δln [KD], respectively. Solid and dashed lines denote the linear regression and boundaries of its 95% confidence interval, calculated by means of software package STATISTICA (Statsoft™, Tulsa, USA); arrows pinpoint the ancestral (WT) and minor (min) alleles of the SNP being studied (rs1452787381 of SHOX), an analysis of which is depicted in Figs. 1 and 2 as an example of the application of our Web service SNP_TATA_Z-tester [41] in this work and its in vitro selective verification here; r, τ, γ, and p are coefficients of Pearson’s linear correlation, Spearman’s rank correlation, Kendall’s rank correlation, and Goodman–Kruskal generalized correlation and their p values, respectively

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