Skip to main content
Fig. 1 | BMC Genetics

Fig. 1

From: Disruptive natural selection by male reproductive potential prevents underexpression of protein-coding genes on the human Y chromosome as a self-domestication syndrome

Fig. 1

The result calculated by SNP_TATA_Z-Tester [41] for candidate SNP marker rs1452787381 of male reproductive potential within the human SHOX gene. a Unannotated SNPs (analyzed in this study) in the 70 bp proximal promoter (where all proven TBP-sites [boxed] are located; double-headed arrow, ↔) of the human SHOX gene retrieved from dbSNP, rel. 151 [8], using the UCSC Genome Browser [11]. Dotted arrow: unannotated SNP rs1452787381 retrieved from dbSNP (b) can be a candidate SNP marker of male reproductive potential as we are predicting here because of a significant change in the affinity of TBP for the human SHOX gene promoter (c). Solid arrows: data input into the two textboxes of our Web service SNP_TATA_Z-tester [41] as two DNA sequence variants of the ancestral (norm, wt) and minor (m) alleles of the SNP under study. Dash-and-dot arrows: estimates of significance of the change in gene product abundance in patients carrying the minor allele (relative to the norm), expressed as a Z-score using the R software [43]. Circles indicate the ancestral and minor alleles of the candidate SNP marker under study

Back to article page