Table 4 Prediction of functional effects of the most deleterious SNPs on the HLA-G1 by MutPred

H117P

0.823

Altered Metal binding

0.27

0.02

confident hypotheses

Altered Transmembrane protein

0.26

1.0e-03

very confident hypotheses

Altered Ordered interface

0.25

0.03

confident hypotheses

H117L

0.665

Altered Transmembrane protein

0.28

4.8e-04

actionable hypotheses

Loss of Strand

0.28

9.6e-03

actionable hypotheses

Altered Metal binding

0.27

0.02

actionable hypotheses

Altered Ordered interface

0.25

0.02

actionable hypotheses

L290R

0.644

Altered Transmembrane protein

0.13

0.02

actionable hypotheses

P234T

0.767

Altered Ordered interface

0.32

1.8e-03

very confident hypotheses

Altered Transmembrane protein

0.25

1.3e-03

very confident hypotheses

R30S

0.792

Altered Ordered interface

0.29

5.0e-03

very confident hypotheses

Loss of Proteolytic cleavage at R30

0.21

1.2e-03

very confident hypotheses

Altered Stability

0.20

0.01

confident hypotheses

Altered Metal binding

0.16

3.5e-03

very confident hypotheses

T158P

0.717

Altered Ordered interface

0.32

3.6e-03

actionable hypotheses

Gain of Relative solvent accessibility

0.29

0.01

actionable hypotheses

Altered Disordered interface

0.28

0.03

actionable hypotheses

Loss of Allosteric site at W157

0.28

7.4e-03

actionable hypotheses

Altered Metal binding

0.27

4.4e-03

actionable hypotheses

Altered Transmembrane protein

0.27

6.6e-04

actionable hypotheses

Loss of Helix

0.27

0.05

actionable hypotheses

Altered Coiled coil

0.10

0.04

actionable hypotheses

Y142C

0.681

Altered Metal binding

0.74

1.1e-03

actionable hypotheses

Altered Disordered interface

0.61

1.7e-04

actionable hypotheses

Altered Ordered interface

0.50

1.7e-04

actionable hypotheses

Altered Transmembrane protein

0.29

2.1e-04

actionable hypotheses

Gain of Relative solvent accessibility

0.27

0.02

actionable hypotheses

Loss of Acetylation at K145

0.20

0.04

actionable hypotheses

Loss of Methylation at K145

0.17

0.01

actionable hypotheses

Loss of Ubiquitylation at K145

0.16

0.04

actionable hypotheses

Gain of Disulfide linkage at Y142

0.09

0.05

actionable hypotheses

Loss of Sulfation at Y147

0.09

3.5e-03

actionable hypotheses

I237F

0.658

Altered Disordered interface

0.33

0.01

actionable hypotheses

Altered Ordered interface

0.28

0.04

actionable hypotheses

Altered Transmembrane protein

0.26

1.1e-03

actionable hypotheses

Loss of Strand

0.26

0.04

actionable hypotheses

Loss of Pyrrolidone carboxylic acid at Q242

0.06

0.02

actionable hypotheses

Q266L

0.444

Altered Ordered interface

0.28

0.03

-

Gain of Relative solvent accessibility

0.26

0.03

Loss of Methylation at K267

0.23

3.8e-03

Gain of Acetylation at K267

0.22

0.02

Loss of Pyrrolidone carboxylic acid at Q266

0.21

1.8e-03

Altered Metal binding

0.20

0.03

Gain of Catalytic site at D262

0.16

0.02

Altered Transmembrane protein

0.15

0.01

Gain of Proteolytic cleavage at D262

0.14

0.02

D53Y

0.746

Altered Ordered interface

0.39

1.1e-03

actionable hypotheses

Altered Disordered interface =)

0.38

6.6e-03

actionable hypotheses

Altered Metal binding

0.37

1.7e-03

actionable hypotheses actionable

Altered Transmembrane protein

0.19

6.6e-03

hypotheses

Loss of Proteolytic cleavage at D53

0.12

0.03

actionable hypotheses

Gain of Pyrrolidone carboxylic acid at Q56

0.09

0.01

actionable hypotheses

Gain of Sulfation at D53

0.07

4.4e-03

actionable hypotheses

W298R

0.822

Altered Ordered interface

0.36

2.1e-03

very confident hypotheses

Altered Transmembrane protein

0.12

0.03

confident hypotheses

C227Y

0.87

Altered Disordered interface

0.42

3.2e-03

very confident hypotheses

Altered Ordered interface

0.39

4.0e-04

very confident hypotheses

Altered Metal binding

0.34

9.6e-03

very confident hypotheses

Altered Transmembrane protein

0.31

1.2e-04

very confident hypotheses

Loss of Helix

0.28

0.03

confident hypotheses

C227F

0.888

Altered Metal binding

0.37

7.8e-03

very confident hypotheses

Altered Disordered interface

0.34

0.01

very confident hypotheses

Altered Ordered interface

0.28

4.3e-03

very confident hypotheses

Loss of Helix

0.27

0.04

confident hypotheses

Altered Transmembrane protein

0.26

9.6e-04

very confident hypotheses

L102P

0.735

Altered Disordered interface

0.36

7.6e-03

actionable hypotheses

Gain of Intrinsic disorder

0.34

0.02

actionable hypotheses

Altered Transmembrane protein

0.31

1.1e-04

actionable hypotheses

Loss of Helix

0.31

4.8e-03

actionable hypotheses

Altered DNA binding

0.25

8.9e-03

actionable hypotheses

Altered Stability

0.21

0.01

actionable hypotheses

Loss of Proteolytic cleavage at R99

0.13

0.02

actionable hypotheses

Y142H

0.667

Altered Metal binding

0.78

8.2e-04

actionable hypotheses

Altered Ordered interface

0.44

5.4e-04

actionable hypotheses

Altered Disordered interface

0.35

8.9e-03

actionable hypotheses

Altered Transmembrane protein

0.31

1.1e-04

actionable hypotheses

Gain of Relative solvent accessibility

0.25

0.03

actionable hypotheses

Gain of Acetylation at K145

0.20

0.04

actionable hypotheses

Loss of Methylation at K145

0.17

0.01

actionable hypotheses

Altered Stability

0.17

0.02

actionable hypotheses

Loss of Ubiquitylation at K145 (

0.15

0.05

actionable hypotheses

Altered Coiled coil

0.10

0.04

actionable hypotheses

Loss of Sulfation at Y147

0.09

3.5e-03

actionable hypotheses

C188S

0.795

Altered Disordered interface

0.29

0.03

confident hypotheses

Altered Ordered interface

0.24

0.03

confident hypotheses

Altered DNA binding

0.17

0.03

confident hypotheses

Altered Transmembrane protein

0.09

0.05

confident hypotheses

P259H

0.607

Altered Metal binding

0.47

5.9e-03

actionable hypotheses

Altered Ordered interface

0.28

0.04

actionable hypotheses

Loss of Loop

0.27

0.02

actionable hypotheses

Altered Transmembrane protein

0.20

5.0e-03

actionable hypotheses

Gain of Catalytic site at D262

0.13

0.03

actionable hypotheses

Loss of Proteolytic cleavage at D262

0.13

0.03

actionable hypotheses

W157R

0.936

Altered Ordered interface

0.37

1.8e-03

very confident hypotheses

Altered Transmembrane protein

0.36

1.5e-05

very confident hypotheses

Gain of Relative solvent accessibility

0.33

3.3e-03

very confident hypotheses

Altered Disordered interface

0.30

0.02

confident hypotheses

Loss of Allosteric site at W157

0.30

3.7e-03

very confident hypotheses

Altered Metal binding

0.28

3.8e-03

very confident hypotheses

Altered Coiled coil

0.27

0.01

confident hypotheses

A229D

0.843

Altered Transmembrane protein

0.34

2.4e-05

very confident hypotheses

Altered Metal binding

0.29

0.02

confident hypotheses

Gain of Relative solvent accessibility

0.28

0.02

confident hypotheses

Altered Ordered interface

0.27

9.8e-03

very confident hypotheses

Q96P

0.683

Loss of Helix

0.30

9.0e-03

actionable hypotheses

Altered Transmembrane protein

0.29

3.0e-04

actionable hypotheses

Altered DNA binding

0.25

6.7e-03

actionable hypotheses

Gain of Ubiquitylation at K92

0.15

0.04

actionable hypotheses

Gain of Proteolytic cleavage at R99

0.13

0.02

actionable hypotheses

Loss of Pyrrolidone carboxylic acid at Q96

0.10

0.01

actionable hypotheses

L294R

0.527

Altered Ordered interface

0.27

8.6e-03

actionable hypotheses

D143N

0.649

Altered Metal binding

0.38

1.5e-03

actionable hypotheses

Altered Transmembrane protein

0.28

3.8e-04

actionable hypotheses

Altered Ordered interface

0.28

0.04

actionable hypotheses

Altered Disordered interface

0.28

0.03

actionable hypotheses

Gain of Relative solvent accessibility

0.26

0.03

actionable hypotheses

Loss of Acetylation at K145

0.19

0.05

actionable hypotheses

Loss of Methylation at K145

0.16

0.01

actionable hypotheses

Loss of Ubiquitylation at K145

0.15

0.04

actionable hypotheses

Loss of Sulfation at Y147

0.09

3.4e-03

actionable hypotheses

D143H

0.738

Altered Metal binding

0.43

7.0e-03

actionable hypotheses

Altered Transmembrane protein

0.32

7.8e-05

actionable hypotheses

Altered Disordered interface

0.29

0.03

actionable hypotheses

Altered Ordered interface

0.27

7.0e-03

actionable hypotheses

Loss of Relative solvent accessibility

0.26

0.03

actionable hypotheses

Loss of Acetylation at K145

0.19

0.05

actionable hypotheses

Loss of Methylation at K145

0.17

0.01

actionable hypotheses

Loss of Ubiquitylation at K145

0.16

0.03

actionable hypotheses

Loss of Sulfation at Y147

0.09

3.3e-03

actionable hypotheses

R205S

0.617

Gain of Intrinsic disorder

0.34

0.02

actionable hypotheses

Altered Ordered interface

0.29

0.03

actionable hypotheses

Loss of Helix

0.27

0.05

actionable hypotheses

Y51C

0.715

Altered Disordered interface

0.60

1.9e-04

actionable hypotheses

Altered Metal binding

0.53

4.1e-03

actionable hypotheses

Altered Ordered interface

0.30

4.6e-03

actionable hypotheses

Loss of Strand

0.27

0.02

actionable hypotheses

Altered Transmembrane protein

0.20

5.0e-03

actionable hypotheses

Loss of Proteolytic cleavage at D53

0.12

0.03

actionable hypotheses

Altered Stability

0.12

0.03

actionable hypotheses

Gain of Pyrrolidone carboxylic acid at Q56

0.08

0.02

actionable hypotheses

Loss of Sulfation at Y51

0.03

0.02

actionable hypotheses

L196P

0.884

Altered Disordered interface

0.34

0.01

confident hypotheses

Altered Ordered interface

0.27

9.0e-03

very confident hypotheses

Altered DNA binding

0.16

0.04

confident hypotheses

Altered Stability

0.14

0.02

confident hypotheses

D54V

0.718

Altered Metal binding

0.55

3.1e-04

actionable hypotheses

Altered Disordered interface

0.40

4.2e-03

actionable hypotheses

Altered Ordered interface

0.25

0.02

actionable hypotheses

Altered Transmembrane protein

0.14

0.02

actionable hypotheses

Loss of Proteolytic cleavage at D53

0.12

0.03

actionable hypotheses

Gain of Pyrrolidone carboxylic acid at Q56

0.09

0.01

actionable hypotheses

Loss of Sulfation at Y51

0.03

0.02

actionable hypotheses

P234L

0.809

Altered Ordered interface

0.33

1.5e-03

very confident hypotheses

Altered Disordered interface

0.30

0.03

confident hypotheses

Altered Transmembrane protein

0.29

2.0e-04

very confident hypotheses

Loss of Strand

0.28

0.01

confident hypotheses

P39L

0.659

Altered Disordered interface

0.27

0.04

actionable hypotheses

Loss of B-factor

0.26

0.04

actionable hypotheses

Altered Transmembrane protein

0.24

1.6e-03

actionable hypotheses

Altered DNA binding

0.23

9.6e-03

actionable hypotheses

Gain of Proteolytic cleavage at R38

0.14

0.02

actionable hypotheses

M29K

0.720

Altered Ordered interface

0.26

0.02

actionable hypotheses

Loss of Proteolytic cleavage at R30

0.20

2.6e-03

actionable hypotheses

Altered Stability

0.13

0.03

actionable hypotheses

Altered Transmembrane protein

0.12

0.03

actionable hypotheses

Altered Metal binding

0.11

7.9e-03

actionable hypotheses

D153G

0.853

Altered Metal binding

0.45

1.6e-04

very confident hypotheses

Altered Disordered interface

0.35

9.1e-03

very confident hypotheses

Loss of Relative solvent accessibility

0.30

8.2e-03

very confident hypotheses

Gain of Strand

0.30

3.1e-03

very confident hypotheses

Altered Transmembrane protein

0.28

4.6e-04

very confident hypotheses

Altered Ordered interface

0.26

0.01

confident hypotheses

Gain of Allosteric site at W157

0.26

7.0e-03

very confident hypotheses

Altered Stability

0.19

0.01

confident hypotheses

Altered Coiled coil

0.10

0.04

confident hypotheses

D130H

0.724

Altered Transmembrane protein

0.30

1.9e-04

actionable hypotheses

Altered Disordered interface

0.28

0.03

actionable hypotheses

Altered Metal binding

0.25

0.03

actionable hypotheses

Loss of Relative solvent accessibility

0.25

0.04

actionable hypotheses

Altered Ordered interface

0.24

0.04

actionable hypotheses

Gain of Disulfide linkage at C125

0.10

0.05

actionable hypotheses

Gain of Catalytic site at D126

0.08

0.05

actionable hypotheses

D244G

0.705

Altered Ordered interface

0.30

0.02

actionable hypotheses

Altered Disordered interface

0.28

0.04

actionable hypotheses

Gain of Strand

0.27

0.02

actionable hypotheses

Altered Transmembrane protein

0.26

8.2e-04

actionable hypotheses

Altered Metal binding

0.18

0.03

actionable hypotheses

Gain of Pyrrolidone carboxylic acid at Q248

0.15

4.6e-03

actionable hypotheses

Loss of Proteolytic cleavage at R243

0.12

0.03

actionable hypotheses

Loss of Catalytic site at R243

0.09

0.04

actionable hypotheses

L105Q

0.507

Altered Disordered interface

0.32

0.01

actionable hypotheses

Gain of Intrinsic disorder

0.30

0.05

actionable hypotheses

Altered Transmembrane protein

0.29

2.1e-04

actionable hypotheses

Altered Ordered interface

0.26

0.01

actionable hypotheses

Altered DNA binding

0.16

0.04

actionable hypotheses

Altered Stability

0.15

0.02

actionable hypotheses

Loss of N-linked glycosylation at N110

0.05

0.02

actionable hypotheses

L105P

0.702

Altered Disordered interface

0.33

0.01

actionable hypotheses

Loss of Helix

0.29

0.01

actionable hypotheses

Altered Transmembrane protein

0.28

3.7e-04

actionable hypotheses

Altered Ordered interface

0.26

0.01

actionable hypotheses

Altered Stability

0.20

0.01

actionable hypotheses

Altered DNA binding

0.16

0.04

actionable hypotheses

Gain of N-linked glycosylation at N110

0.05

0.02

actionable hypotheses