Amyloid-β peptides slightly affect lifespan or antimicrobial peptide gene expression in Drosophila melanogaster

BMC Genomic Data

Table 2 Cox proportional hazards analysis. Proportional hazard modeled for Aβ peptide (treatment versus control) and vials (10 vials in each experimental variant) as covariates with partial likelihood estimation

Variant	Risk factor	HR	SE	P-value
Aβ42 males	vial	1.048	0.015	0.001
Aβ42 males	Aβ peptide	0.924	0.085	0.355
Aβ42 females	vial	0.971	0.029	0.313
Aβ42 females	Aβ peptide	1.201	0.083	0.028
isoD7-Aβ42 males	vial	1.054	0.015	0.001
isoD7-Aβ42 males	Aβ peptide	1.008	0.043	0.848
isoD7-Aβ42 females	vial	0.971	0.029	0.313
isoD7-Aβ42 females	Aβ peptide	0.993	0.043	0.861
pS8-Aβ42 males	vial	1.005	0.004	0.159
pS8-Aβ42 males	Aβ peptide	0.961	0.029	0.179
pS8-Aβ42 females	vial	0.971	0.029	0.313
pS8-Aβ42 females	Aβ peptide	1.013	0.028	0.643

Hazard ratios (HR) indicates fold change of the hazard (risk of death) for variants with higher values of that variable. The risk factor Aβ peptide is encoded by 1 (untreated control) and 2 (treated with Aβ peptide). The vials are numbered from 1 to 10 in each experimental variant as pseudoreplicates. HR greater than one indicates increased risk of death. Significant estimates in bold. SE - standard error

ISSN: 2730-6844