Fig. 1

Effects of the amyloid-β peptides on lifespan (a, b), locomotor activity (c, d), and gene expression (e, f) in males (a, c, e) and females (b, d, f). *р < 0.05, **р < 0.01, ***p < 0.001, log-rank test (survival data comparison), Fisher’s exact test (median lifespan (dM) comparison), and Student’s t-test (comparison of locomotor activity and gene expression). The error bars show standard errors. For lifespan analysis the total number of flies (n) used in two replicates (5 vials in each) is indicated in parentheses. For locomotor activity and qRT-PCR analyses the number of flies (n) used in each replication of experiment multiplied by the number of replicates are indicated in parentheses. For detailed description see Materials and methods