Associations between potentially functional CORIN SNPs and serum corin levels in the Chinese Han population

BMC Genomic Data

Table 2 Association between CORIN gene polymorphisms and serum corin levels and incident hypertension

SNP	Position	MA	MAF %	HWE^*	Corin				Hypertension
SNP	Position	MA	MAF %	HWE^*	Beta	P	Beta^#	P ^#	OR(95%CI)	P	OR(95%CI)^#	P ^#
rs2289433	exon 1	G	34.3	0.075	0.035	0.052	0.037	0.040	1.08(0.92,1.26)	0.358	1.13(0.96,1.34)	0.152
rs6823184	intron 1	C	43.5	0.870	0.036	0.033	0.038	0.024	0.95(0.82,1.11)	0.509	0.90(0.77,1.06)	0.220
rs10008014	intron 6	C	24.6	0.289	−0.002	0.883	0.000	0.990	0.99(0.84,1.18)	0.931	1.02(0.85,1.22)	0.853
rs17654423	intron 6	C	26.6	0.670	−0.020	0.510	− 0.019	0.319	1.02(0.87,1.20)	0.801	1.02(0.86,1.22)	0.804
rs10517195	exon 9	G	15.7	0.167	0.074	0.001	0.074	0.002	0.94(0.77,1.16)	0.568	0.93(0.76,1.16)	0.515
rs2271037	intron 9	T	38.7	0.551	0.042	0.022	0.042	0.015	1.01(0.87,1.17)	0.911	0.97(0.83,1.14)	0.736
rs2351784	intron 11	T	23.0	0.335	−0.014	0.615	−0.012	0.854	0.92(0.77,1.10)	0.348	0.90(0.75,1.09)	0.288
rs12509275	intron 17	G	13.8	0.064	0.073	0.003	0.070	0.004	1.01(0.82,1.25)	0.913	0.94(0.75,1.18)	0.573
rs3749585	exon 22	C	48.0	0.774	−0.001	0.814	−0.006	0.737	0.99(0.85,1.14)	0.852	0.98(0.84,1.15)	0.834

HWE Hardy–Weinberg equilibrium; MA Minor allele; MAF Minor allele frequency
*: P value for HWE using Fisher’s exact test
#: Adjusted for smoking, drinking, BMI, TC, TG, HDL-C, FBG, family history of hypertension

ISSN: 2730-6844