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Table 1 The two-stage MO-GWAS and joint analysis results of 52 SNPs

From: Genome-wide association study of morbid obesity in Han Chinese

CHRSNPPOSITIONGene (Nearest)Minor Allele1st Stage2nd StageJoint analysis (1st + 2nd)
ORSERaw-pORSERaw-pORSERaw-pBonferroni
(Raw-p ×  52)
16rs805013653,816,275FTOA1.730.112.11E-071.370.099.37E-041.510.077.80E-10$4.13E-08*
16rs993960953,820,527FTOA1.730.112.20E-071.350.101.58E-031.510.071.32E-09$7.00E-08*
16rs142108553,800,954FTOC1.650.101.31E-061.320.093.18E-031.460.071.54E-08$8.16E-07*
16rs994134953,825,488FTOT1.620.092.82E-071.420.184.83E-021.480.079.05E-084.80E-06*
16rs112198053,809,247FTOA1.590.091.16E-061.190.095.35E-021.360.067.27E-073.85E-05*
16rs993735453,799,847FTOA1.570.091.18E-061.380.187.46E-021.430.076.65E-073.52E-05*
16rs129258466,926,667RBFOX1G0.680.096.04E-060.870.086.68E-020.780.066.21E-063.29E-04*
16rs172353356,928,991RBFOX1G0.690.091.30E-050.880.088.06E-020.790.051.26E-056.68E-04*
14rs1162695651,850,031N/AG1.400.089.57E-061.090.072.39E-011.230.053.35E-050.0018*
18rs212601565,545,054RP11-638 L3.1C0.700.081.76E-050.900.071.69E-010.810.054.64E-050.0025*
12rs15970229,748,233TMTC1C1.440.097.31E-051.150.088.60E-021.250.061.50E-040.0080*
20rs606947754,491,980CBLN4A1.400.089.40E-061.050.075.02E-011.200.052.87E-040.015*
8rs16883931113,664,153CSMD3G1.360.087.40E-051.120.071.22E-011.200.053.99E-040.021*
2rs6757087212,680,523ERBB4G1.460.085.19E-071.000.079.68E-011.190.055.49E-040.029*
2rs980843418,694,885N/AC1.450.091.29E-051.050.085.59E-011.200.068.83E-040.047*
8rs7262145764,548,431LOC102724612G0.700.095.12E-050.960.085.64E-010.830.061.12E-030.059
4rs12649045122,957,607TRPC3, KIAA1109T0.710.081.40E-051.030.077.12E-010.850.051.31E-030.069
8rs310499496,571,283LOC100616530, C8orf37-AS1C1.540.114.84E-051.030.107.43E-011.240.071.84E-030.098
5rs258019115,807,688CTB-118 N6.3 / SEMA6AC0.740.088.26E-050.980.077.29E-010.860.052.39E-030.13
1rs300348217,550,601PADI1G0.700.081.02E-051.000.079.65E-010.860.053.01E-030.16
18rs7601019365,526,327RP11-638 L3.1T0.730.085.21E-050.980.077.54E-010.860.052.89E-030.15
9rs7459650889,361,079LOC102724080, GAS1G0.600.142.71E-040.950.268.38E-010.710.123.19E-030.17
3rs485903388,518,323N/AG0.730.082.03E-040.930.083.67E-010.850.063.85E-030.20
5rs34971115,795,188CTB-118 N6.3 / SEMA6AT1.360.084.25E-050.990.078.63E-011.150.054.34E-030.23
12rs713626958,075,937RPL13AP23 (Pseudo), OS9A0.730.089.66E-051.020.159.19E-010.840.064.71E-030.25
4rs98559163,331,949N/AT1.390.091.28E-041.020.088.37E-011.170.065.22E-030.28
13rs957197569,218,765RPS3AP52 (Pseudo), RPL12P34 (Pseudo)A1.470.093.02E-050.940.094.81E-011.190.065.75E-030.30
5rs7939392580,873,159SSBP2C0.460.211.47E-040.760.211.86E-010.670.155.84E-030.31
12rs1087699458,064,737RPL13AP23 (Pseudo)A0.750.081.60E-041.120.154.59E-010.850.066.15E-030.33
11rs257582614,474,971N/AT0.630.122.00E-040.980.118.69E-010.810.086.64E-030.35
16rs20518625,574,869N/AT1.520.124.98E-041.050.116.67E-011.240.087.49E-030.40
3rs59778278120,809,596STXBP5LA0.530.152.31E-050.890.144.00E-010.770.101.04E-020.55
16rs23714026,645,648N/AC0.540.155.79E-051.070.125.95E-010.800.091.51E-020.80
18rs1768180150,173,621DCCC1.350.081.92E-041.020.088.18E-011.130.051.90E-021.01
3rs117383450168,549,587N/AA0.470.213.98E-040.960.178.09E-010.740.132.11E-021.12
8rs310499996,555,479LOC100616530, C8orf37-AS1A1.330.082.73E-041.000.079.49E-011.120.052.35E-021.25
15rs1695946533,129,842FMN1G0.750.083.58E-041.030.076.64E-010.890.052.37E-021.26
1rs3516084,384,773N/AG0.720.104.45E-040.940.197.42E-010.840.082.32E-021.23
4rs235006466,709,201N/AT1.500.111.71E-041.000.109.76E-011.170.072.48E-021.31
17rs4655633,513,719SHPK / TRPV1G1.460.083.04E-060.910.072.06E-011.120.052.92E-021.55
8rs1010674352,371,648PXDNLT0.580.164.85E-040.990.309.77E-010.760.133.10E-021.64
12rs476379912,462,567LRP6, MANSC1C0.710.091.64E-041.050.085.34E-010.880.063.23E-021.71
13rs957196169,167,161LOC102724158T1.480.092.05E-050.880.091.78E-011.140.063.57E-021.89
9rs20826328,794,253PTPRDG0.750.084.63E-041.050.075.09E-010.900.054.30E-022.28
8rs7266416990,126,780N/AA1.340.081.25E-040.940.073.84E-011.100.055.21E-022.76
12rs6191953763,058,514PPM1HC0.620.131.35E-041.100.103.72E-010.860.085.90E-023.13
1rs3516074,384,296RP5-1166F10.1 (Pseudo)G0.700.102.30E-041.030.097.23E-010.890.066.56E-023.48
5rs17741008150,896,898FAT2 / SLC36A1T0.710.104.30E-041.080.083.89E-010.900.067.45E-023.95
2rs2892923165,438,473GRB14C1.670.123.38E-050.770.135.04E-021.130.081.57E-018.32
1rs425958969,972,693N/AG0.750.084.45E-041.160.073.88E-020.930.051.90E-0110.07
6rs690798018,401,381RNF144BA1.350.083.07E-040.880.081.15E-011.060.052.76E-0114.63
3rs144990722,573,833N/AG0.730.092.61E-041.130.079.45E-020.950.053.04E-0116.11
  1. CHR chromosome, SE standard error, Raw-p: raw p-value. $: p-value < 5 × 10−8; *: Bonferroni correction p-value (raw-p x 52) <  0.05