Table 3 Genotype and allele frequencies for rs10252701 (AHR) and rs79105258 (CUX2) according to habitual coffee consumption level
SNP | Coffee consumption (Cups/day) | ||||
|---|---|---|---|---|---|
Allele | 0.00 | 0.00–1.00 | 1.00–3.00 | 3.00–10.00 | |
rs10252701 | AA [N (%)] | 740 (43.7) | 1151 (43.4) | 2481 (46.6) | 1339 (52.2) |
N = 12,239 | CA [N (%)] | 753 (44.5) | 1204 (45.4) | 2311 (43.4) | 1010 (39.4) |
CC [N (%)] | 200 (11.8) | 299 (11.3) | 535 (10.0) | 216 (8.4) | |
OR (95% CI) | 1 (ref.) | 1.00 (0.91–1.09) | 0.90 (0.83–0.98) | 0.76 (0.69–0.84) | |
P | – | 0.92 | 0.01 | 9.1 × 10−9 | |
rs79105258 | CC [N (%)] | 1015 (60.0) | 1594 (60.1) | 2960 (55.6) | 1269 (49.5) |
N = 12,239 | AC [N (%)] | 578 (34.1) | 872 (32.9) | 2040 (38.3) | 1089 (42.5) |
AA [N (%)] | 100 (5.9) | 188 (7.1) | 327 (6.1) | 207 (8.1) | |
OR (95% CI) | 1 (ref.) | 1.03 (0.93–1.14) | 1.13 (1.04–1.24) | 1.39 (1.26–1.54) | |
P | – | 0.58 | 6.7 × 10−3 | 1.4 × 10−10 | |