|
Variant
|
Chr
|
Position
|
Gene
|
EA
|
NEA
|
Population
|
EAF
|
Beta
|
SE (Beta)
|
P
association
|
I
2
|
P
heterogeneity
|
|---|
|
rs518341
|
1
|
78,896,492
|
GIPC2– PTGFR
|
G
|
A
|
Discovery
|
0.315
|
0.133
|
0.030
|
6.4 × 10− 6
|
–
|
–
|
| | | | | |
Replication
|
0.317
|
0.009
|
0.030
|
0.77
|
–
|
–
|
| | | | | |
Meta-analysis
|
0.316
|
0.072
|
0.021
|
5.9 × 10−4
|
88.6
|
3.1 × 10−3
|
|
rs11722777
|
4
|
7,590,819
|
SORCS2
|
A
|
G
|
Discovery
|
0.816
|
−0.167
|
0.037
|
6.4 × 10−6
|
–
|
–
|
| | | | | |
Replication
|
0.821
|
−0.075
|
0.038
|
0.05
|
–
|
–
|
| | | | | |
Meta-analysis
|
0.819
|
−0.123
|
0.027
|
3.9 × 10−6
|
66.3
|
0.08
|
|
rs10941308
|
5
|
36641,007
|
SLC1A3
|
A
|
G
|
Discovery
|
0.115
|
0.189
|
0.043
|
9.3 × 10−6
|
–
|
–
|
| | | | | |
Replication
|
0.118
|
−0.026
|
0.044
|
0.55
|
–
|
–
|
| | | | | |
Meta-analysis
|
0.117
|
0.084
|
0.031
|
5.8 × 10−3
|
92.0
|
4.2 × 10−4
|
|
rs10648495
|
6
|
162,128,756
|
PRKN
|
CTCTTT
|
C
|
Discovery
|
0.463
|
−0.130
|
0.028
|
4.5 × 10−6
|
–
|
–
|
| | | | | |
Replication
|
0.459
|
0.040
|
0.029
|
0.16
|
–
|
–
|
| | | | | |
Meta-analysis
|
0.461
|
−0.046
|
0.020
|
0.02
|
94.4
|
2.4 × 10−5
|
|
rs10252701
|
7
|
17,280,513
|
AHR
|
C
|
A
|
Discovery
|
0.322
|
−0.194
|
0.031
|
3.2 × 10−10
|
–
|
–
|
| | | | | |
Replication
|
0.308
|
−0.146
|
0.032
|
4.0 × 10−6
|
–
|
–
|
| | | | | |
Meta-analysis
|
0.315
|
−0.171
|
0.022
|
1.0 × 10−14
|
15.1
|
0.28
|
|
rs79105258
|
12
|
111,718,231
|
CUX2
|
A
|
C
|
Discovery
|
0.268
|
0.211
|
0.032
|
4.4 × 10−11
|
–
|
–
|
| | | | | |
Replication
|
0.298
|
0.137
|
0.031
|
1.3 × 10−5
|
–
|
–
|
| | | | | |
Meta-analysis
|
0.283
|
0.173
|
0.022
|
9.5 × 10−15
|
63.2
|
0.10
|
- Chr Chromosome number, EA Effect allele, NEA Non-effect allele, EAF Effect allele frequency, SE Standard error
