TY - JOUR AU - Nayeri, S. AU - Schenkel, F. AU - Fleming, A. AU - Kroezen, V. AU - Sargolzaei, M. AU - Baes, C. AU - Cánovas, A. AU - Squires, J. AU - Miglior, F. PY - 2019 DA - 2019/07/16 TI - Genome-wide association analysis for β-hydroxybutyrate concentration in Milk in Holstein dairy cattle JO - BMC Genetics SP - 58 VL - 20 IS - 1 AB - Ketosis in dairy cattle has been shown to cause a high morbidity in the farm and substantial financial losses to dairy farmers. Ketosis symptoms, however, are difficult to identify, therefore, the amount of ketone bodies (mainly β-hydroxybutyric acid, BHB) is used as an indicator of subclinical ketosis in cows. It has also been shown that milk BHB concentrations have a strong correlation with ketosis in dairy cattle. Mid-infrared spectroscopy (MIR) has recently became a fast, cheap and high-throughput method for analyzing milk components. The aim of this study was to perform a genome-wide association study (GWAS) on the MIR-predicted milk BHB to identify genomic regions, genes and pathways potentially affecting subclinical ketosis in North American Holstein dairy cattle. SN - 1471-2156 UR - https://doi.org/10.1186/s12863-019-0761-9 DO - 10.1186/s12863-019-0761-9 ID - Nayeri2019 ER -