BMC Genomic Data

Table 2 P values from paired Mann-Whitney U Test between Biobank and Wellderly for different subsets of nonsynonymous SNPs

From: Genome-wide analysis indicates association between heterozygote advantage and healthy aging in humans

	All genes				OMIM recessive genes				OMIM dominant genes
	SNP#	MAF	HET_O	F^a	SNP#	MAF	HET_O	F^a	SNP#	MAF	HET_O	F^a
0.01 ≤ MAF < 0.05	3731	0.107	0.201	0.750	219	0.053	0.056	0.648	87	9.7e-4 ^c	0.002 ^c	0.07
0.05 ≤ MAF < 0.1	1243	0.638	0.459	0.095	81	0.089	0.688	0.189	30	0.155	0.430	0.626
0.1 ≤ MAF < 0.25	1548	0.049	0.003 ^b	0.101	66	0.645	0.710	0.954	35	0.276	0.30	0.518
0.25 ≤ MAF < 0.5	1175	0.126	0.133	0.359	61	0.401	0.007 ^b	0.015^b	20	0.896	0.856	0.588
Total	7697	0.30	0.165	0.608	427	0.612	0.042^b	0.112	172	0.053	0.035^c	0.133

P values in bold pass multiple testing correction (FDR adjusted P < 0.1)
^aF: excess of heterozygosity
^bDirection: Biobank < Wellderly
^cDirection: Biobank > Wellderly

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ISSN: 2730-6844

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