Skip to main content

Table 2 Associations of six SNPs in PRKG1 gene with milk fatty acid traits (LSM ± SE)

From: A post-GWAS confirming effects of PRKG1 gene on milk fatty acids in a Chinese Holstein dairy population

SNP

Genotype (No.)

C6:0 (%)

C8:0 (%)

C10:0 (%)

C11:0 (%)

C12:0 (%)

C13:0 (%)

C14:0 (%)

C14:1 (%)

C15:0 (%)

C16:0 (%)

C16:1 (%)

C17:0 (%)

 g.8344262A > T

AA(424–459)

0.4901 ± 0.0122

0.9658 ± 0.0107

2.8472 ± 0.0321Aa

0.0577 ± 0.0023

2.9861 ± 0.0418

0.0988 ± 0.0028

10.2891 ± 0.0702

0.6447 ± 0.0180

0.9972 ± 0.0122

34.7950 ± 0.1771

1.3324 ± 0.0248ab

0.5664 ± 0.0031

AT(259–393)

0.4735 ± 0.0125

0.9467 ± 0.0109

2.7685 ± 0.0332Bb

0.0581 ± 0.0025

2.9584 ± 0.0423

0.0991 ± 0.0030

10.1625 ± 0.0716

0.6598 ± 0.0187

0.9947 ± 0.0127

34.7954 ± 0.1822

1.3529 ± 0.0257a

0.5714 ± 0.0032

TT(96–104)

0.4769 ± 0.0174

0.9366 ± 0.0150

2.8580 ± 0.0438ABa

0.0559 ± 0.0035

2.9889 ± 0.0572

0.0965 ± 0.0047

10.3280 ± 0.0951

0.6555 ± 0.0271

0.9880 ± 0.0188

34.9466 ± 0.2566

1.2643 ± 0.0356b

0.5709 ± 0.0047

P

0.2405

0.0177

0.0012**

0.8124

0.6385

0.8615

0.0297

0.6391

0.8733

0.7983

0.0295

0.1829

 g.6904047G > T

GG(420–458)

0.4580 ± 0.0133

0.9292 ± 0.0119

2.8354 ± 0.0350

0.0580 ± 0.0026

3.0006 ± 0.0449

0.0988 ± 0.0032

10.2605 ± 0.0777a

0.6579 ± 0.0199

0.9950 ± 0.0133

34.8344 ± 0.1923

1.2995 ± 0.0272a

0.5621 ± 0.0034

GT(179–196)

0.4682 ± 0.0155

0.9361 ± 0.0131

2.8250 ± 0.0394

0.0584 ± 0.0030

2.9910 ± 0.0502

0.0987 ± 0.0039

10.0941 ± 0.0865b

0.6642 ± 0.0229

1.0011 ± 0.0159

34.9128 ± 0.2225

1.3677 ± 0.0312b

0.5678 ± 0.0040

TT(21–24)

0.5161 ± 0.0316

0.8947 ± 0.0258

2.8551 ± 0.0727

0.0538 ± 0.0064

3.0339 ± 0.0974

0.0947 ± 0.0085

10.1180 ± 0.1720ab

0.6469 ± 0.0489

0.9967 ± 0.0346

34.7830 ± 0.4581

1.3050 ± 0.0656ab

0.5592 ± 0.0085

P

0.1453

0.2466

0.8812

0.7751

0.8935

0.8846

0.0377

0.9145

0.9096

0.9003

0.0304

0.2151

 g.6903810G > A

AA(17–21)

0.5425 ± 0.0347

1.0524 ± 0.0269A

2.7307 ± 0.0780

0.0547 ± 0.0070

2.8806 ± 0.1040

0.0922 ± 0.0096

10.3798 ± 0.1808

0.6550 ± 0.0523

0.9345 ± 0.0366

34.3377 ± 0.4963

1.2467 ± 0.0677

0.5534 ± 0.0091

AG(179–191)

0.4720 ± 0.0146

0.9352 ± 0.0127B

2.7669 ± 0.0373

0.0580 ± 0.0029

2.9549 ± 0.0484

0.0977 ± 0.0037

10.2389 ± 0.0820

0.6663 ± 0.0225

1.0024 ± 0.0153

34.8727 ± 0.2159

1.3247 ± 0.0301

0.5686 ± 0.0039

GG(681–741)

0.4849 ± 0.0114

0.9418 ± 0.0102B

2.8293 ± 0.0309

0.0592 ± 0.0022

3.0072 ± 0.0393

0.1001 ± 0.0026

10.2294 ± 0.0664

0.6561 ± 0.0169

0.9969 ± 0.0114

34.7215 ± 0.1659

1.3250 ± 0.0233

0.5674 ± 0.0029

P

0.1040

<.0001**

0.0464

0.7411

0.1944

0.6019

0.6868

0.8697

0.1831

0.4741

0.4903

0.2478

 g.6903365C > A

AA(93–107)

0.4439 ± 0.0206Aa

0.9343 ± 0.0169A

2.8432 ± 0.0489

0.0586 ± 0.0041

3.0238 ± 0.0635

0.1018 ± 0.0053

10.4947 ± 0.1101

0.6549 ± 0.0305

1.0037 ± 0.0211

34.7232 ± 0.2894

1.2476 ± 0.0410

0.5653 ± 0.0053

CC(361–381)

0.5229 ± 0.0138Bb

0.9924 ± 0.0122B

2.8967 ± 0.0367

0.0592 ± 0.0027

3.0341 ± 0.0471

0.0997 ± 0.0033

10.3851 ± 0.0799

0.6661 ± 0.0206

0.9927 ± 0.0140

34.9631 ± 0.2004

1.3330 ± 0.0283

0.5662 ± 0.0035

CA(49–55)

0.4626 ± 0.0240ABa

0.9379 ± 0.0196A

2.8406 ± 0.0566

0.0576 ± 0.0048

2.9559 ± 0.0745

0.1039 ± 0.0063

10.1970 ± 0.1278

0.6478 ± 0.0365

0.9746 ± 0.0254

34.2494 ± 0.3514

1.2822 ± 0.0488

0.5598 ± 0.0063

P

<.0001**

<.0001**

0.2980

0.9415

0.5068

0.7647

0.0958

0.8336

0.6052

0.0875

0.0569

0.5867

 g.6902878 T > G

GG(189–202)

0.4323 ± 0.0169A

0.9624 ± 0.0144Aa

2.8052 ± 0.0423

0.0559 ± 0.0033

2.9744 ± 0.0550

0.0973 ± 0.0042

10.1691 ± 0.0957a

0.6547 ± 0.0252

0.9966 ± 0.0172

34.7964 ± 0.2433

1.3831 ± 0.0341

0.5667 ± 0.0044

GT(2)

0.7892 ± 0.0983B

1.3588 ± 0.0820B

3.1626 ± 0.2348

0.0560 ± 0.0212

3.0685 ± 0.3132

0.0971 ± 0.0288

11.5294 ± 0.5289b

0.5671 ± 0.1627

0.9937 ± 0.1135

34.7693 ± 1.5091

1.1787 ± 0.2088

0.5358 ± 0.0283

TT(306–334)

0.4942 ± 0.0161C

0.9916 ± 0.0137Ab

2.8670 ± 0.0409

0.0595 ± 0.0032

3.0380 ± 0.0527

0.1015 ± 0.0040

10.2332 ± 0.0918a

0.6368 ± 0.0243

1.0049 ± 0.0166

34.8385 ± 0.2325

1.3627 ± 0.0326

0.5671 ± 0.0042

P

<.0001**

<.0001**

0.0426

0.4274

0.2875

0.5502

0.0249

0.6194

0.8525

0.9768

0.4788

0.5390

 g.6901713 T > G

GG(21–27)

0.5161 ± 0.0328AB

1.0577 ± 0.0246A

2.8817 ± 0.0710AB

0.0539 ± 0.0064

2.8762 ± 0.0928

0.1008 ± 0.0083

10.0821 ± 0.1607ab

0.5555 ± 0.0474

0.9906 ± 0.0333

34.1191 ± 0.4451

1.3422 ± 0.0617

0.5699 ± 0.0083

GT(266–289)

0.4958 ± 0.0132A

0.9797 ± 0.0116B

2.9305 ± 0.0345A

0.0579 ± 0.0026

3.0584 ± 0.0448

0.1000 ± 0.0033

10.3430 ± 0.0756a

0.6518 ± 0.0201

0.9971 ± 0.0137

34.8534 ± 0.1956

1.3099 ± 0.0273

0.5649 ± 0.0035

TT(591–637)

0.4628 ± 0.0116B

0.9230 ± 0.0103C

2.8342 ± 0.0310B

0.0579 ± 0.0023

3.0024 ± 0.0397

0.0982 ± 0.0027

10.1984 ± 0.0673b

0.6604 ± 0.0171

0.9930 ± 0.0115

34.9830 ± 0.1682

1.3285 ± 0.0237

0.5711 ± 0.0030

P

0.0029*

<.0001**

0.0004**

0.8083

0.0545

0.8097

0.0181

0.0734

0.9357

0.1082

0.6493

0.1080

SNP

Genotype (No.)

C17:1 (%)

C18:0 (%)

C18:1cis-9 (%)

C18index (%)

C20:0 (%)

C14index (%)

C16index (%)

C17index (%)

SFA (%)

UFA (%)

SFA/UFA (%)

Total index (%)

 g.8344262A > T

AA(374–460)

0.1906 ± 0.0025a

14.0884 ± 0.0864

18.9343 ± 0.1167a

56.9012 ± 0.2735ab

0.1685 ± 0.0017

6.0733 ± 0.1384

3.6217 ± 0.0636AB

24.8838 ± 0.2156a

68.1683 ± 0.1617

30.2498 ± 0.1462

2.2891 ± 0.0212

27.5332 ± 0.1278A

AT(331–393)

0.1957 ± 0.0026b

14.0342 ± 0.0907

19.2495 ± 0.1212b

57.3243 ± 0.2805a

0.1706 ± 0.0017

6.2370 ± 0.1435

3.6885 ± 0.0659A

24.9935 ± 0.2245a

67.9305 ± 0.1671

30.4415 ± 0.1520

2.2709 ± 0.0221

27.9090 ± 0.1313B

TT(82–104)

0.1889 ± 0.0036ab

14.2026 ± 0.1381

18.7636 ± 0.1828a

56.3603 ± 0.4109b

0.1699 ± 0.0027

6.1182 ± 0.2045

3.4344 ± 0.0913B

24.1599 ± 0.3177b

68.4212 ± 0.2469

29.9512 ± 0.2243

2.3224 ± 0.0329

27.1715 ± 0.1948A

P

0.0218

0.4469

0.0031*

0.0323

0.3960

0.3704

0.0101

0.0154

0.0770

0.0628

0.2492

<.0001**

 g.6904047G > T

GG(382–459)

0.1909 ± 0.0027Aa

14.0083 ± 0.0952

19.0595 ± 0.1295

57.3442 ± 0.2994

0.1668 ± 0.0020a

6.2722 ± 0.1517

3.6249 ± 0.0698

24.9868 ± 0.2379A

68.0210 ± 0.1771

30.3843 ± 0.1611

2.2734 ± 0.0232

27.7337 ± 0.1392

GT(173–196)

0.1951 ± 0.0031ABa

14.0877 ± 0.1147

19.0396 ± 0.1519

56.9780 ± 0.3490

0.1718 ± 0.0023b

6.3520 ± 0.1778

3.7536 ± 0.0798

25.1566 ± 0.2723A

68.1127 ± 0.2102

30.3983 ± 0.1887

2.2768 ± 0.0275

27.7040 ± 0.1642

TT(22–24)

0.2129 ± 0.0064Bb

14.2950 ± 0.2501

18.9209 ± 0.3330

56.8847 ± 0.7389

0.1642 ± 0.0045ab

6.0245 ± 0.3750

3.5526 ± 0.1650

26.8471 ± 0.5501B

67.8471 ± 0.4476

30.4643 ± 0.4116

2.2507 ± 0.0598

27.7666 ± 0.3516

P

0.0010**

0.4300

0.9118

0.4383

0.0190

0.6321

0.1072

0.0021*

0.7890

0.9791

0.9099

0.9710

 g.6903810G > A

AA(16–21)

0.1852 ± 0.0068

14.2381 ± 0.2711

19.4313 ± 0.3637

57.8248 ± 0.8116

0.1630 ± 0.0053AB

5.8672 ± 0.3861

3.5731 ± 0.1706

25.0782 ± 0.5779

67.6381 ± 0.4921

30.6643 ± 0.4476

2.1938 ± 0.0634

28.8024 ± 0.3790Aa

AG(154–191)

0.1907 ± 0.0030

14.2502 ± 0.1111

18.9316 ± 0.1477

56.9864 ± 0.3386

0.1751 ± 0.0021A

6.1871 ± 0.1691

3.6361 ± 0.0768

24.9321 ± 0.2611

68.1679 ± 0.2033

30.2696 ± 0.1845

2.3059 ± 0.0266

27.4558 ± 0.1589Bb

GG(622–743)

0.1907 ± 0.0023

14.0972 ± 0.0800

19.1316 ± 0.1076

57.5775 ± 0.2508

0.1692 ± 0.0016B

6.1143 ± 0.1313

3.6545 ± 0.0602

24.8228 ± 0.2058

67.8738 ± 0.1482

30.4623 ± 0.1352

2.2670 ± 0.0196

27.8031 ± 0.1169ABc

P

0.6965

0.3037

0.1962

0.1177

0.0027*

0.6719

0.8620

0.8107

0.2087

0.4195

0.1027

0.0006**

 g.6903365C > A

AA(86–107)

0.1840 ± 0.0041

13.8722 ± 0.1550

19.4709 ± 0.2047a

57.9027 ± 0.4677

0.1597 ± 0.0031A

6.0759 ± 0.2298

3.4734 ± 0.1041

24.7990 ± 0.3588

67.7737 ± 0.2806

30.7073 ± 0.2542a

2.2474 ± 0.0368

28.0306 ± 0.2207a

CC(322–383)

0.1898 ± 0.0028

14.0896 ± 0.1003

18.8996 ± 0.1348b

57.0679 ± 0.3097

0.1652 ± 0.0020AB

6.2036 ± 0.1599

3.6362 ± 0.0727

25.0637 ± 0.2475

68.2830 ± 0.1841

30.0458 ± 0.1674b

2.3118 ± 0.0244

27.4913 ± 0.1448b

CA(44–55)

0.1908 ± 0.0049

14.0436 ± 0.1845

19.2701 ± 0.2468ab

57.5534 ± 0.5502

0.1736 ± 0.0037B

6.2137 ± 0.2664

3.5773 ± 0.1236

25.4468 ± 0.4221

67.8333 ± 0.3333

30.3655 ± 0.3056ab

2.2236 ± 0.0451

28.0080 ± 0.2610ab

P

0.2709

0.3586

0.0103

0.1432

0.0032*

0.8193

0.2198

0.3687

0.0975

0.0221

0.0476

0.0114

 g.6902878 T > G

GG(162–202)

0.1990 ± 0.0034a

14.1712 ± 0.1255

19.2493 ± 0.1668

57.8214 ± 0.3823

0.1723 ± 0.0025

6.2335 ± 0.1958

3.7811 ± 0.0867

25.7488 ± 0.2926

67.8664 ± 0.2288

30.4505 ± 0.2085

2.2678 ± 0.0303

27.9791 ± 0.1799

GT(1–2)

0.1396 ± 0.0210b

15.1152 ± 0.8492

17.5963 ± 1.1241

55.1627 ± 2.4664

0.2174 ± 0.0205

4.6700 ± 1.1690

3.2808 ± 0.5268

22.3692 ± 1.7890

70.2243 ± 1.4970

27.7265 ± 1.3769

2.6772 ± 0.1992

25.8210 ± 1.1776

TT(298–334)

0.1937 ± 0.0033a

13.9941 ± 0.1205

19.0195 ± 0.1603

57.8556 ± 0.3675

0.1697 ± 0.0024

6.0736 ± 0.1867

3.6985 ± 0.0842

25.3001 ± 0.2887

68.1192 ± 0.2203

30.2583 ± 0.1994

2.2932 ± 0.0291

27.8464 ± 0.1728

P

0.0035*

0.1368

0.1045

0.5484

0.0342

0.2492

0.3232

0.0318

0.1353

0.0844

0.0802

0.1353

 g.6901713 T > G

GG(23–27)

0.1820 ± 0.0064AB

14.2657 ± 0.2465

19.3224 ± 0.3331

57.4973 ± 0.7218

0.1618 ± 0.0046

5.3282 ± 0.3472a

3.6417 ± 0.1598

24.7738 ± 0.5396AB

67.7758 ± 0.4361

30.6385 ± 0.4050

2.2379 ± 0.0579

28.0440 ± 0.3424

GT(241–289)

0.1866 ± 0.0027A

14.0054 ± 0.0977

18.9266 ± 0.1306

57.1601 ± 0.3031

0.1707 ± 0.0019

6.0394 ± 0.1533ab

3.6135 ± 0.0702

24.4844 ± 0.2400A

68.2066 ± 0.1805

30.1259 ± 0.1638

2.2896 ± 0.0240

27.4588 ± 0.1422

TT(524–639)

0.1960 ± 0.0024B

14.1040 ± 0.0818

19.1405 ± 0.1105

57.1691 ± 0.2570

0.1715 ± 0.0016

6.2935 ± 0.1335b

3.6568 ± 0.0609

25.1479 ± 0.2074B

68.0575 ± 0.1524

30.3322 ± 0.1387

2.2695 ± 0.0201

27.7208 ± 0.1193

P

<.0001**

0.3793

0.1310

0.8921

0.0925

0.0034*

0.7300

0.0019*

0.4593

0.2162

0.4936

0.0446

  1. Note: LSM least square mean, SE standard error. P indicates the significances of the association analysis between each SNP and milk fatty acid traits. P is the raw value. *: P < 0.0083 (the significant association analysis after multiple testing, 0.05/N). **: P < 0.0017 (the significant association analysis after multiple testing, 0.01/N). N is the number of SNPs. Different letter (small letters: P < 0.05; capital letters: P < 0.01) superscripts indicate significant differences among the genotypes. The number in the brackets represents the number of cows for the corresponding genotype