TY - JOUR AU - Yu, Jingting AU - Hu, Ming AU - Li, Chun PY - 2019 DA - 2019/04/30 TI - Joint analyses of multi-tissue Hi-C and eQTL data demonstrate close spatial proximity between eQTLs and their target genes JO - BMC Genetics SP - 43 VL - 20 IS - 1 AB - Gene regulation is important for cells and tissues to function. It has been studied from two aspects at the genomic level, the identification of expression quantitative trait loci (eQTLs) and identification of long-range chromatin interactions. It is important to understand their relationship, such as whether eQTLs regulate their target genes through physical chromatin interaction. Although chromatin interactions have been widely believed to be one of the main mechanisms underlying eQTLs, most evidence came from studies of cell lines and yet no direct evidence exists for tissues. SN - 1471-2156 UR - https://doi.org/10.1186/s12863-019-0744-x DO - 10.1186/s12863-019-0744-x ID - Yu2019 ER -