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Table 3 Lead SNP from genome-wide associated regions for milk yield in Nordic Holstein cattle. Base positions are given as position in UMD 3.1.1 [49]

From: Dissecting closely linked association signals in combination with the mammalian phenotype database can identify candidate genes in dairy cattle

BTA

base position

Imputation accuracy

Effect

–log10(p)

Region

Gene

Annotation

2

80,753,895

0.9454

1.13

9.95

79,777,813~81,003,948

NABP1 (near)

intergenic

3

56,402,959

0.9308

−1.36

11.68

56,152,966~56,653,364

ENSBTAG00000001873 (near)

intergenic

4

101,547,644

0.7008

−1.66

12.65

100,921,921~101,798,041

CHRM2 (near)

upstream

5

93,953,487

0.9726

−2.10

29.52

93,703,737~94,203,599

MGST1 (near)

upstream

5

31005518b

0.9943

1.42

12.25

30,202,453~31,258,920

WNT1 (near)

upstream

5

85080296c

0.7619

−1.28

11.24

84,425,435~85,330,671

KRAS (near)

intergenic

5

20569435d

0.9944

1.23

9.37

19,600,731~20,820,066

CCER1 (near)

intergenic

6

88,847,595

0.9009

−1.78

21.61

88,598,011~89,097,608

GC (near)

intergenic

6

46901490b

0.7413

−1.28

11.45

46,181,675~47,152,919

SEL1L3 (near)

intergenic

6

38027010c

0.9950

−4.75

9.47

37,669,181~38,279,802

ABCG2

missense

7

65,370,850

0.9848

−1.36

13.58

65,120,872~65,620,985

GLRA1 (near)

intergenic

8

73,877,814

0.8453

−1.37

11.14

73,629,406~74,127,901

ENSBTAG00000010829 (near)

upstream

8

42062591b

0.9595

−1.27

10.07

41,064,643~42,313,291

KCNV2 (near)

intergenic

9

33,478,527

0.8801

−1.25

9.23

32,627,954~33,728,755

ENSBTAG00000015497 (near)

intergenic

10

1,989,907

0.9469

−1.15

9.92

1,016,031~2,240,288

ENSBTAG00000047622 (near)

intergenic

13

36,822,330

0.9933

−1.66

10.74

36,572,364~37,072,486

MPP7

intron

14a

1,802,667

0.7975

5.98

178.35

1,545,264~2,044,412

DGAT1

intron

15

54,392,611

0.9577

1.57

16.58

53,485,007~54,642,856

PPME1

intron

16

28,384,260

0.9984

1.64

10.50

28,012,864~28,634,313

CNIH3 (near)

intergenic

17

66,510,224

0.9438

1.83

11.63

66,119,023~66,760,263

CORO1C

intron

18

46,583,346

0.9829

1.86

11.97

46,333,384~46,833,392

UPK1A (near)

upstream

19

27,442,452

0.7904

−1.26

9.71

26,592,355~27,692,965

bta-mir-497 (near)

downstream

20

29,996,719

0.9580

−2.95

31.02

29,748,423~30,246,822

MRPS30 (near)

intergenic

23

25,076,472

0.9797

−1.34

9.23

24,219,868~25,326,583

GCM1

intron

26

37,716,420

0.9790

−1.43

12.28

36,730,021~ 37,966,463

SHTN1 (near)

intergenic

28

34,972,377

0.9991

1.18

9.81

34,722,402~35,222,855

ZMIZ1 (near)

intergenic

Total number of significant SNPs

55,600

  1. aEight additional SNPs on chromosome 14 had same highest P value. Note, bindicated this SNP was found on second round, cindicated this SNP was found on third round, dindicated this SNP was found on fourth round