Fig. 2
From: Vps4b heterozygous mice do not develop tooth defects that replicate human dentin dysplasia I
Histopathological analysis of mandibular first molars of mice with increased pre-dentin width. Histopathological analysis of mandibular first molars in 1 (A, B), 3 (C), and 6 (D) month-old mice. Compared with WT mice (a, e, i, and m), the pre-dentin width was reduced and the mineralized dentin width was increased in heterozygous mice (c, g, k, and o). A Longitudinal sections of a representative 1-month-old mouse tooth. B, C, and D Cross-sections of representative 1-, 3-, and 6-month-old mouse teeth. High-power magnification (b, d, f, h, j, l, n, and p) from the area inside the black box in low-magnification images (a, c, e, g, i, k, m, and o). The black arrows refer to the inner pre-dentin. Abbreviations: de, dentin; p, pulp; pd., pre-dentin