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Table 1 Gene Enrichment of targets in WT group

From: p.E95K mutation in Indian hedgehog causing brachydactyly type A1 impairs IHH/Gli1 downstream transcriptional regulation

GO biological process complete

Mus musculus - REFLIST (22262)

Gene sets in WT

Expected

Over/under

Fold Enrichment

Raw P-value

FDR

Sensory perception of smell (GO:0007608)

1089

82

34.05

+

2.41

1.33E-12

2.05E-08

Sensory perception of chemical stimulus (GO:0007606)

1377

92

43.05

+

2.14

2.91E-11

1.49E-07

G-protein coupled receptor signaling pathway (GO:0007186)

1793

111

56.06

+

1.98

1.73E-11

1.33E-07

Sensory perception (GO:0007600)

1757

102

54.93

+

1.86

4.68E-09

1.20E-05

Nervous system process (GO:0050877)

2120

115

66.28

+

1.74

1.72E-08

3.77E-05

System process (GO:0003008)

2592

133

81.04

+

1.64

2.42E-08

4.14E-05

Signaling (GO:0023052)

4966

227

155.26

+

1.46

7.79E-10

3.00E-06

Cell communication (GO:0007154)

5084

231

158.95

+

1.45

1.04E-09

3.20E-06

Signal transduction (GO:0007165)

4629

206

144.72

+

1.42

6.62E-08

1.02E-04

Multicellular organismal process (GO:0032501)

7058

293

220.66

+

1.33

1.77E-08

3.41E-05

Cellular response to stimulus (GO:0051716)

6089

242

190.37

+

1.27

2.37E-05

2.80E-02

Cellular process (GO:0009987)

13,831

486

432.41

+

1.12

2.96E-05

3.25E-02

Biological_process (GO:0008150)

20,540

671

642.16

+

1.04

1.17E-05

1.50E-02

Unclassified (UNCLASSIFIED)

1722

25

53.84

–

0.46

1.17E-05

1.64E-02