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Table 2 Design elements of studies addressing fenofibrate treatment effects

From: Detecting responses to treatment with fenofibrate in pedigrees

First Named Author

Outcome Variable

Genetic & Genomic Predictors

Baseline Measures

PCs

Covariates Included

Treatment of Family Data

Cantor

Post ML sib corrs & SDs, meQTL

SNPs

Pre ML sib corrs & SDs

  

LMM

Cherlin

Ln (postTG)

SNPs

Ln (preTG)

20

Age, center, smoking

PCs

Hsu

PreTG

SNPs

 

4

Age, sex, center

LMM Independents

Wu

Ln (postML − preML)

SNPs

 

10

Age, sex, batch, smoking

LMM

Xia

(PostTG − preTG)/preTG

Binary TG

 

PreTG

10

Age, sex, smoking, ML

Empirical kinships

Xu

PostTG − preTG

SNPs

 

10

Age, center, ATP, smoking, IDF

LMM

Yang

PostTG − preTG

SNPs

 

10

Age, sex, center, ATP, smoking, IDF

GEE

Yasmeen

Ln (postTG)

ML, SNPs

Ln (preTG)

none

Age

Independents

  1. ATP Adult Treatment Panel, IDF International Diabetes Federation, LMM linear mixed model, Ln natural logarithm, meQTL methylation quantitative trait locus, ML Methylation levels, PCs Number of principal components; pre, pretreatment; post, posttreatment, SDs Standard deviations; sib corrs, sibling correlations, SNPs Single-nucleotide polymorphisms, TG Triglyceride levels