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Table 1 Association results between SNPs associated with TGs (TG1–2or TG3–4 or ΔTG1–4) under the POO model and nearby DNA methylation probes associated with TGs (TG2 or ΔTG2–4), with or without taking the POO effect into account

From: Investigation of parent-of-origin effects induced by fenofibrate treatment on triglycerides levels

SNP Chr:Pos (Mb) Gene Pheno Alleles a1/a2 Freq a1 TGs = SNP + covariates TGs = Meth2 + covariates Meth2 = SNP + covariates + TGs
P P of P ot P om_op P op_om Probe Pos (Mb) P P P of P ot P om_op P op_om
rs2903839 2:56.17   TG1–2 A/G 0.59 0.16 2.7 × 10−7 1.5 × 10− 7 1.8 × 10− 6 0.01 cg07468585 56.2 0.02 0.53 0.02 0.39 0.21 0.01
            cg25249448 56.2 0.03 0.55 0.04 0.16 0.62 0.01
rs13131918 4:24.87 CCDC149 TG1–2 A/G 0.52 0.07 2.8 × 10−7 1.4 × 10−7 0.004 7.0 × 10−7 cg09490880 24.9 0.04 0.02 0.72 0.52 0.42 0.85
rs7300117 12:131.7   TG1–2 A/T 0.52 6.2 × 10−9 3.8 × 10−5 0.07 0.11 3.9 × 10− 5 cg09481537 131.7 0.04 0.09 0.06 0.16 0.70 0.02
rs301621 16:86.65   ΔTG1–4 G/T 0.60 0.18 1.5 × 10−5 0.01 0.40 1.2 × 10− 5 cg10206250 86.6 0.04 0.19 0.02 0.008 0.01 0.10
rs10417097* 19:19.72 PBX4 TG1–2 C/G 0.62 0.01 3.0 × 10−5 6.4 × 10−5 0.23 8.0 × 10−6 cg10738025 19.7 0.03 0.005 0.47 0.92 0.34 0.49
rs10417097* 19:19:72 PBX4 TG3–4 C/G 0.62 0.009 3.0 × 10−6 6.8 × 10−6 0.13 8.5 × 10−7
  1. *SNP located in a locus previously reported to be associated with TGs (rs17216525-T, beta = 0.11, P = 4.0 × 10− 11)
  2. Statistical significances of: (a) the test when maternal and paternal inherited alleles are modeled separately (βpat = βmat = 0, P of), (b) the test for difference between paternal and maternal transmissions (βpat = βmat, P ot), (c) the test of maternal effect only (βmat = 0, P om_op), and (d) the test of paternal effect only (βpat = 0, P op_om)
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