Skip to main content

Table 2 Variation in estimated intra- and interclass correlation coefficients across relative paired groups and subtypes (N > 50) at 3 MetS-related CpG methylation loci unadjusted and adjusted for fixed covariates in 993 participants from 188 families with nonmissing covariates and methylation information at visit 2 in the GOLDN study

From: Characterization of the contribution of shared environmental and genetic factors to metabolic syndrome methylation heritability and familial correlations

Pair Type Na Familial Correlations
Expectationb cg00574958 at CPT1A cg17058475 at CPT1A cg18181703 in SOCS3 cg06500161 in ABCG1
h2 = 0.316 h2 = 0.355 h2 = 0.566 h2 = 0.306
Unadj. Adj. Unadj. Adj. Unadj. Adj. Unadj. Adj.
Parent–offspring 541 h2/2 0.1721 0.1578 0.0986 0.0900 0.2964 0.2887 0.2267 0.2081
Mother–daughter 158 h2/2 0.2240 0.2565 0.2094 0.2572 0.2590 0.2591 0.1755 0.1537
Mother–son 146 h2/2 0.2302 0.1868 0.0750 0.0625 0.2207 0.2525 0.1775 0.1766
Father–daughter 129 h2/2 0.0422 0.0729 0.1766 0.1774 0.4510 0.4239 0.3417 0.3415
Father–son 108 h2/2 0.1967 0.2588 0.0480 0.0172 0.2813 0.2477 0.2071 0.1982
Siblings 588 h2/2 0.2224 0.1906 0.2071 0.2043 0.3295 0.3114 0.1185 0.1039
Brother–brother 145 h2/2 0.2396 0.2333 0.2328 0.2359 0.2668 0.2413 0.0647 0.0555
Sister–brother 276 h2/2 0.2075 0.1562 0.1496 0.1556 0.3252 0.2774 0.1187 0.0978
Sister–sister 167 h2/2 0.2245 0.3141 0.2680 0.2517 0.3769 0.3577 0.1490 0.1478
Grandparents–grandchildren 75 h2/4 0.0924 0.1020 0.0781 0.0807 0.3342 0.2892 0.0164 0.0064
Avuncular 553 h2/4 0.0685 0.0893 0.1323 0.1272 0.1440 0.1691 0.1632 0.1410
First cousins 247 h2/8 0.0227 0.0007 − 0.0393 − 0.0584 − 0.1394 − 0.1392 0.1411 0.1362
Great-avuncular 53 h2/8 0.0005 0.0266 0.1279 0.2092 − 0.0215 − 0.0453 0.5514 0.5249
First cousins once removed 71 h2/16 0.0486 0.1987 0.3085 0.2066 − 0.2466 − 0.2190 0.2418 0.1984
Parent–parent 65 0 0.1412 0.1221 − 0.0982 − 0.1432 0.0507 0.0164 0.0613 0.0505
Unrelatedc 91 0 − 0.0089 − 0.0236 0.0126 − 0.0231 − 0.0181 − 0.0235 − 0.0011 − 0.0002
MS Concordant 91 0 0.1420 0.1130 0.1602 0.1270 − 0.0399 − 0.0580 − 0.0051 − 0.0408
MS Discordant 76 0 − 0.1354 − 0.1284 − 0.1547 − 0.1515 − 0.1718 − 0.1566 0.0291 0.1017
  1. Values in bold represent estimates that are nonzero with a P value < 0.05
  2. Abbreviations: Adj. Calculated on residuals created after adjusting for fixed covariates age, age2, sex, center, and current smoking, MS National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Metabolic Syndrome status at visit 2, Unadj. unadjusted for any covariates
  3. aPairings may not be independent
  4. bThe expected correlation under a genetic model with a heritability of h2
  5. cOverall unrelated correlation assigned by subsetting to the 182 individuals from distinct families and randomly pairing them, whereas concordant and discordant strata were calculated after randomly pairing within or across the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults criteria for MetS cases (N = 76) and controls (N = 106)