Skip to main content

Table 1 Variation in estimated additive heritability at three MetS-related CpG methylation loci adjusted (Model 0) and across increasing adjustments for demographic and environmental factors (Models 1–2), in a reduced model of fixed effects, and after including to this reduced model separate variance components for shared early life (Model 3a) and late life environment (Model 3b) in 993 participants from 188 families with all covariates and methylation information at visit 2 in the GOLDN study

From: Characterization of the contribution of shared environmental and genetic factors to metabolic syndrome methylation heritability and familial correlations

Modela

Log Likelihood

h2 (c2)

SE of h2 (c2)

P value of h2 (c2)

Prop Var Exp by Cov

cg00574958 at CPT1A

 0

− 560.399

0.292

0.064

2E-7

 1

− 513.830

0.325

0.066

2E-8

0.085

 2a

− 511.765

0.319

0.066

4E-8

0.089

 2b

−509.989

0.311

0.066

1E-7

0.094

 1–2 (Reduced)

−511.893

0.316

0.062

1E-7

0.089 (age, age2, sex, age*sex age2*sex, current smoking)

 3a

− 510.396

0.251 (0.090)

0.082 (0.055)

1E-3 (4E-2)

0.091

 3b

− 508.105

0.359 (0.256)

0.074 (0.087)

1E-8 (3E-3)

0.089

cg17058475 at CPT1A

 0

− 692.475

0.302

0.069

4E-7

 1

− 668.034

0.365

0.071

4E-9

0.038

 2a

− 665.591

0.356

0.071

9E-9

0.042

 2b

− 662.173

0.351

0.071

1E-8

0.051

 1–2 (Reduced)

− 666.050

0.355

0.071

8E-9

0.043 (age, current smoking)

 3a

−665.471

0.298 (0.062)

0.092 (0.060)

8E-4 (1E-1)

0.044

 3b

NC

    

cg18181703 in SOCS3

 0

− 555.561

0.486

0.063

8E-18

 1

− 518.163

0.557

0.063

2E-21

0.055

 2a

− 517.421

0.551

0.064

4E-21

0.058

 2b

−514.324

0.559

0.063

1E-21

0.062

 1–2 (Reduced)

− 515.994

0.566

0.063

3E-22

0.057 (age, age2, center, current and former smoking)

 3a

−515.889

0.553 (0.020)

0.071 (0.045)

1E-11 (3E-1)

0.062

 3b

−515.663

0.585 (0.085)

0.068 (0.104)

2E-22 (2E-1)

0.060

cg06500161 in ABCG1

 0

− 195.927

0.323

0.070

3E-8

 1

−181.366

0.330

0.069

1E-8

0.028

 2a

−177.208

0.313

0.069

1E-7

0.039

 2b

−176.433

0.305

0.069

1E-7

0.041

 1–2 (Reduced)

− 184.146

0.306

0.069

1E-7

0.026 (sex, center)

 3b

NC

    

 3c

NC

    
  1. Abbreviations: c2 Household variance component, h2 heritability variance component, NC nonconvergence of the household variance component model(s), Prop Var Exp by Covar proportion of variance explained by covariates, SNP single nucleotide polymorphisms
  2. aThe fixed covariates introduced in a stepwise fashion across Models 1 (age, age2, sex, age*sex, age2*sex), 2a (center), and 2b (current and former smoking, indicator variables) were then screened at p < 0.1, to yield a reduced model. Then in Models 3a (‘early life’ shared environment, 647 siblings or half-siblings, within 15 years of each other in 255 households) and 3b (‘later life’ shared environment; 128 parents, or in the case of multiple pairings those with the youngest offspring, in 64 households) variance components were separately introduced individually to this reduced model