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Table 4 The results of functional analysis of targets of predicted microRNAs

From: Molecular mechanism of estrogen-mediated neuroprotection in the relief of brain ischemic injury

 

Category

Term

Count

PValue

Genes

 

BP

GO:0045737~positive regulation of cyclin-dependent protein kinase activity

2

0.002892

CCND1, ADAM17

 

BP

GO:0000079~regulation of cyclin-dependent protein kinase activity

2

0.009065

CCND1, ADAM17

 

BP

GO:0000082~G1/S transition of mitotic cell cycle

2

0.015209

CCND1, ADAM17

 

BP

GO:0009719~response to endogenous stimulus

3

0.020374

KCNMA1, CCND1, ADAM17

 

BP

GO:0045787~positive regulation of cell cycle

2

0.023758

CCND1, ADAM17

 

BP

GO:0051592~response to calcium ion

2

0.026189

KCNMA1, CCND1

 

BP

GO:0051329~interphase of mitotic cell cycle

2

0.026594

CCND1, ADAM17

MIR-338

MF

GO:0030165~PDZ domain binding

2

0.026878

ATP2B1, ADAM17

 

BP

GO:0051325~interphase

2

0.027403

CCND1, ADAM17

 

BP

GO:0042981~regulation of apoptosis

3

0.027951

KCNMA1, ETS1, ADAM17

 

BP

GO:0043067~regulation of programmed cell death

3

0.028656

KCNMA1, ETS1, ADAM17

 

BP

GO:0010941~regulation of cell death

3

0.028892

KCNMA1, ETS1, ADAM17

 

BP

GO:0001934~positive regulation of protein amino acid phosphorylation

2

0.038676

CCND1, ADAM17

 

BP

GO:0010604~positive regulation of macromolecule metabolic process

3

0.040483

CCND1, ETS1, ADAM17

 

BP

GO:0051272~positive regulation of cell motion

2

0.040678

ETS1, ADAM17

 

BP

GO:0042327~positive regulation of phosphorylation

2

0.042677

CCND1, ADAM17

 

BP

GO:0045937~positive regulation of phosphate metabolic process

2

0.043874

CCND1, ADAM17

 

BP

GO:0032844~regulation of homeostatic process

2

0.045867

ETS1, ADAM17

 

BP

GO:0051726~regulation of cell cycle

3

0.013609

CCND1, SFRS5, CITED2

MIR520D

BP

GO:0010552~positive regulation of specific transcription from RNA polymerase II promoter

2

0.037336

ETS1, CITED2

 

BP

GO:0045787~positive regulation of cell cycle

2

0.042363

CCND1, CITED2

 

BP

GO:0051592~response to calcium ion

2

0.046653

KCNMA1, CCND1

 

BP

GO:0019228~regulation of action potential in neuron

2

0.048792

KCNMA1, SCD

MIR-376A, MIR-376B

CC

GO:0043025~cell soma

2

0.046407

ADNP, GRIN3A

  1. BP biological process, CC cellular component