Multivariate genome-wide association analysis identifies novel and relevant variants associated with anterior cruciate ligament rupture risk in the dog model

Table 2 SNPs associated with multivariate phenotype of anterior cruciate ligament rupture (ACLR), tibial plateau angle (TPA), and relative tibial tuberosity width (rTTW)

SNP	Chr	Position	BF_mult	BF_ACLR	BF_TPA	BF_rTTW	Gene	Location	Exon Dist. (Kb)
BICF2G630788965	1	95183740	3.07	0.78	-0.23	1.75	ROR2	95124036-95282085	51.9
BICF2P1286728	4	42104780	3.10	0.68	2.18	-0.24	DOCK2	41779969-42177966	0.34
BICF2P1160758 TIGRP2P303751_rs8873754	23 23	26140588 26148612	3.37	4.24	-0.16	-0.11	(lncRNA)	26107359-26132719	N/A

Table shows log₁₀Bayes Factors (BF) for multivariate association test as well as univariate tests. BF_mult, result for multivariate phenotype; BF_ACLR, ACL rupture only; BF_TPA, tibial plateau angle only; BF_rTTW, relative tibial tuberosity width only. SNPs on chromosomes 1 and 4 were located within intronic regions of genes. The distance from the SNP location to the nearest gene exon is reported (Exon Dist.). The locus on chromosome 23 resides in a region <8Kb from a long non-coding RNA (lncRNA)

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