Table 6 Summary of enriched Gene Ontology (GO) molecular function (MF) terms among total identified Pfam protein family domains
term_ID | description | Frequencya | log10 p-value | Uniquenessb |
|---|---|---|---|---|
GO:0003700 | sequence-specific DNA binding transcription factor activity | 5.30% | −10.6576 | 0.958 |
GO:0003712 | transcription cofactor activity | 1.78% | −39.8861 | 0.957 |
GO:0003824 | catalytic activity | 37.22% | −13.4559 | 0.972 |
GO:0004871 | signal transducer activity | 11.94% | −25.4318 | 0.927 |
GO:0004930 | G-protein coupled receptor activity | 7.87% | −27.6198 | 0.925 |
GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 0.48% | −11.699 | 0.956 |
GO:0005216 | ion channel activity | 2.49% | −13.9208 | 0.896 |
GO:0015075 | ion transmembrane transporter activity | 5.28% | −5.7959 | 0.895 |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 4.60% | −58.7447 | 0.771 |
GO:0004672 | protein kinase activity | 3.87% | − 14.1308 | 0.772 |
GO:0043015 | gamma-tubulin binding | 0.10% | −25.8539 | 0.878 |
GO:0008017 | microtubule binding | 1.06% | −16.4815 | 0.848 |
GO:0019001 | guanyl nucleotide binding | 2.48% | −25.4318 | 0.846 |
GO:0005509 | calcium ion binding | 3.94% | −19.0655 | 0.863 |
GO:0005515 | protein binding | 26.71% | −7.3665 | 0.92 |
GO:0004488 | methylenetetrahydrofolate dehydrogenase (NADP+) activity | 0.02% | −13.4559 | 0.878 |
GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | 0.26% | −19.9208 | 0.876 |
GO:0003777 | microtubule motor activity | 0.51% | −45.6021 | 0.814 |
GO:0005544 | calcium-dependent phospholipid binding | 0.17% | −19.0655 | 0.844 |
GO:0042802 | identical protein binding | 4.77% | −25.8539 | 0.878 |
GO:0031683 | G-protein beta/gamma-subunit complex binding | 0.16% | −25.4318 | 0.883 |
GO:0043565 | sequence-specific DNA binding | 4.31% | −10.6576 | 0.855 |
GO:0016787 | hydrolase activity | 15.05% | −7.8861 | 0.841 |
GO:0008484 | sulfuric ester hydrolase activity | 0.11% | −31.7447 | 0.832 |
GO:0004181 | metallocarboxypeptidase activity | 0.15% | −32.6778 | 0.809 |
GO:0004222 | metalloendopeptidase activity | 0.79% | −15 | 0.79 |
GO:0019901 | protein kinase binding | 1.80% | −7.2007 | 0.885 |
GO:0008479 | queuine tRNA-ribosyltransferase activity | 0.02% | −34.7447 | 0.849 |
GO:0003676 | nucleic acid binding | 21.33% | −8.6021 | 0.849 |
GO:0005102 | receptor binding | 6.56% | −62.1871 | 0.875 |
GO:0004402 | histone acetyltransferase activity | 0.24% | −51.3372 | 0.812 |
GO:0003677 | DNA binding | 10.28% | −9.5376 | 0.843 |
GO:0008408 | 3′-5′ exonuclease activity | 0.18% | −31.0655 | 0.827 |
GO:0016746 | transferase activity, transferring acyl groups | 1.42% | −30.9208 | 0.805 |
GO:0003723 | RNA binding | 7.68% | −5.9208 | 0.847 |
GO:0046872 | metal ion binding | 20.96% | −4.5376 | 0.845 |
GO:0004550 | nucleoside diphosphate kinase activity | 0.14% | −55.585 | 0.816 |
GO:0008236 | serine-type peptidase activity | 1.32% | −7.1739 | 0.793 |
GO:0008270 | zinc ion binding | 6.73% | −4.2076 | 0.856 |
GO:0004129 | cytochrome-c oxidase activity | 0.43% | −12.5686 | 0.809 |
GO:0003924 | GTPase activity | 1.03% | −25.4318 | 0.806 |
GO:0005524 | ATP binding | 8.83% | −14.1308 | 0.751 |
GO:0000166 | nucleotide binding | 14.40% | −7.3565 | 0.823 |
GO:0003810 | protein-glutamine gamma-glutamyltransferase activity | 0.07% | −14.7696 | 0.823 |
GO:0005543 | phospholipid binding | 1.33% | −16.6021 | 0.829 |
GO:0035091 | phosphatidylinositol binding | 0.84% | −17 | 0.829 |