From: TelNet - a database for human and yeast genes involved in telomere maintenance
Method | Organism / cell line | # genes/proteins | Ref. |
---|---|---|---|
Proteomics of isolated chromatin segments (PICh) | human / Wi38-VA13 HeLa 1.2.11 | 296 | [14] |
Quantitative telomeric chromatin isolation protocol (QTIP) | human / HeLa | 34 | [38] |
Protein network analysis surrounding telomere repeat binding factors, TRF1, TRF2, and POT1 using dual-tag affinity purification in combination with multidimensional protein identification technology liquid chromatography - tandem mass spectrometry (MudPIT LC-MS/MS) | human / 293 T | 211 | [16] |
Protein complementation assay (PCA/bimolecular fluorescent complementation (BiFC)) of shelterin compounds and ~ 12.000 candidate genes; GST-pulldown of FLAG-tagged genes | human / HTC75 | 339 | [17] |
siRNA mediated knockdown; APB formation | human / U2OS | 29 | |
Proteomic analysis of deregulated genes upon telomere shortening caused by the telomerase inhibitor GRN163 | human / SK-N-MC | 99 | [24] |
QTRAP: kinase library screen | human / HeLa | 109 | [18] |
Telomerase regulators affecting its transcription | human / various | 53 | [19] |
Gene set with potential relevance to telomeres and the ALT pathway | human / various | 297 | [41] |
Telomerase activity signature | human | 43 | [40] |
GO annotation containing the term “telo” | human | 245 | [44] |
Haploid deletion screen, telomere length | yeast | 166 | [26] |
Telomere length-variation screen in deletion strains | yeast | 138 | [27] |
Screen of DAmP collection | yeast | 77 | [28] |
Telomerase null screen of yeast mutants | yeast | 270 | [42] |
Telomerase regulators from the Yeastract database | yeast | 35 | [43] |
GO annotation containing the term “telo” | yeast | 192 | [44] |