Table 3 The spectrum of HBB gene mutations in the regional hot-spot of South Asia and Southeast Asia

1

Bangladesh

c.79G > A, c.92 + 5 G > C, c.126_129delCTTT, c.92 G > C, c.27_28insG, c.47G > A, c.92 G > A, c.46delT, c.92 + 130 G > C, and c.51delC

[13, 14]

2

India: West Bengal, Uttar Pradesh, Eastern India, Southern India

c.92 + 5 G > C, c.92 + 1G > C, c.27_28insG, c.47G > A, c.51delC, c.92 + 5 G > C, c.126_129delCTTT

[23]

3

Sri Lanka

c.92 + 5 G > C, c.92 + 1G > C, c.79G > A, c.92 G > C, c.27_28insG, c.47G > A, c.51delC, c.126_129delCTTT

[24]

4

Malaysia

c.92 + 5 G > C, c.92 + 1 G > C, c.59A > G, c.126_129delCTTT, c.52A > T, c.27_28insG, c.216_217insA, c.92 + 1 G > C, c.79G > A

[25]

5

Thailand

c.126_129delCTTT, c.52A > T, c.59A > G, c.27_28insG, c.92 + 1 G > C, c.92 + 5 G > C, c.108C > A, c.47G > A

[26]

6

Pakistan

c.92 + 5 G > C, c.27_28insG, c.92 + 1G > C, c.126_129delCTTT, c.92 G > A, c.17_18delCT and c.47G > A

[27]

7

Mayanmar

c.92 + 1 G > T, c.126_129delCTTT, c.92 + 5 G > C, c.53A > T, c.135delC, c.108C > A, c.47G > A, c.51delC, c.46delT, c.92 + 1 G > C, c.27_28insG, c.126delC

[28]