Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies

BMC Genomic Data

Table 1 Real data application. Marginal genetic effects for the associations of three GSTP1 & TNF SNPs with parents reported physician-diagnosed asthma from birth to 7–8 years of age in the pooled TAG data and in GINIplus considering a dominant mode of inheritance for the three SNPs

^aAdjusted for study, city, intervention, infant sex, maternal age at birth, maternal smoking during pregnancy, environmental tobacco smoke in the home, birth weight, and parental atopy. ^bp-values were corrected for multiple testing using the Bonferroni method (raw p-values multiplied by the number of analyzed SNPs (3)). ^cPooled data from BAMSE, CAPPS, GINIplus, LISAplus, SAGE and PIAMA, N, ORs and p-values as published in MacIntyre et al. (2014). ^ddetermined for this publication

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