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Fig. 3 | BMC Genetics

Fig. 3

From: Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies

Fig. 3

Power, sign-misspecifications and type I error comparison of the GRS-interaction-training approach (one half of the data used as training data and the other half as test data) vs. the GRS-marginal-internal approach. Scenarios with predominant interaction effects (a) and predominant marginal genetic effects (b). Minor allele frequencies of the 6 risk SNPs increase from 0.01 to 0.45, scenarios with 6, 50 and 100 noise SNPs (N = 1000 observations and 100 replications)

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