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Table 9 Top ten targeter miRNAs for both Human and Rhesus monkey (that are connected with maximum number of gene-modules and that target maximum number genes from the connected modules) with information of their maximum number of targeted genes as well as gene-modules, and verified information of them for inter-species analysis

From: Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus

Sl. No. MiRNAs Number of connected gene-modules Number of targeted genes Name of the connected gene-modules (number of targeted genes in the modules) Disease-verified information of TFs for human Status of TFs for human Disease-verified information of TFs for rhesus Status of TFs for rhesus
1 miR-19b 14 121 Black (8), Blue (18), Brown (9), Green (3), Gray60 (1), Lightyellow (1), Magenta (2), Pink (1), Purple (1), Red (9), Salmon (1), Tan (1), Turquoise (45), Yellow (21). associated with Alzeimer’s disease [71] Known - Unknown
2 miR-19a 14 119 Black (8), Blue (18), Brown (8), Green (3), Gray60 (1), Lightyellow (1), Magenta (2), Pink (1), Purple (1), Red (9), Salmon (1), Tan (1), Turquoise (44), Yellow (21). HIV mediated neurodegenerative disease [39] Known - Unknown
3 miR-520d-5p 12 130 Black (8), Blue (14), Brown (21), Green (4), Greenyellow(1), Magenta (2), Pink (1), Purple (1), Red (8), Tan (1), Turquoise (52), Yellow (17). Alzeimer’s disease [76] Known - Unknown
4 miR-524-5p 12 130 Black (8), Blue (14), Brown (21), Green (4), Greenyellow(1), Magenta (2), Pink (1), Purple (1), Red (8), Tan (1), Turquoise (52), Yellow (17). neuroblastoma [77] Known Amyotrophic lateral sclerosis [59]. Known
5 miR-519b-5p 12 109 Black (4), Blue (19), Brown (10), Green (1), Lightcyan(1), Lightyellow(1), Magenta (3), Pink (1), Red (11), salmon(1), Turquoise (43), Yellow (14). glioma [47] Known - Unknown
6 miR-519a 12 109 Black (4), Blue (19), Brown (10), Green (1), Lightcyan(1), Lightyellow(1), Magenta (3), Pink (1), Red (11), salmon(1), Turquoise (43), Yellow (14). down syndrome related AD [77] Known - Unknown
7 miR-519c-3p 12 109 Black (4), Blue (19), Brown (10), Green (1), Lightcyan(1), Lightyellow(1), Magenta (3), Pink (1), Red (11), salmon(1), Turquoise (43), Yellow (14). neuroblastoma [77] Known - Unknown
8 miR-495 12 102 Black (3), Blue (17), Brown (8), Green (7), Greenyellow(1), Lightcyan(1), Lightyellow(1), Magenta (2), purple(2), Red (8), Turquoise (40), Yellow (12). HIV mediated dementia [39] Known Age mediated skeletal muscle contamination [54] Known
9 miR-944 11 138 Black (6), Blue (22), Brown (18), Green (3), Lightyellow(1), Magenta (1), Midnightblue(1), Purple(1), Red (11), Turquoise (57), Yellow (17). Cancer metastasis in brain [70] Known - Unknown
10 miR-664 11 123 Black (10), Blue (17), Brown (9), Cyan(1), Green (6), Magenta (2), Purple(1), Red (13), Tan(1) Turquoise (46), Yellow (17). Psychiatric and Neurodegenerative disease [44]. Known - Unknown