Table 9 Top ten targeter miRNAs for both Human and Rhesus monkey (that are connected with maximum number of gene-modules and that target maximum number genes from the connected modules) with information of their maximum number of targeted genes as well as gene-modules, and verified information of them for inter-species analysis
Sl. No. | MiRNAs | Number of connected gene-modules | Number of targeted genes | Name of the connected gene-modules (number of targeted genes in the modules) | Disease-verified information of TFs for human | Status of TFs for human | Disease-verified information of TFs for rhesus | Status of TFs for rhesus |
|---|---|---|---|---|---|---|---|---|
1 | miR-19b | 14 | 121 | Black (8), Blue (18), Brown (9), Green (3), Gray60 (1), Lightyellow (1), Magenta (2), Pink (1), Purple (1), Red (9), Salmon (1), Tan (1), Turquoise (45), Yellow (21). | associated with Alzeimer’s disease [71] | Known | - | Unknown |
2 | miR-19a | 14 | 119 | Black (8), Blue (18), Brown (8), Green (3), Gray60 (1), Lightyellow (1), Magenta (2), Pink (1), Purple (1), Red (9), Salmon (1), Tan (1), Turquoise (44), Yellow (21). | HIV mediated neurodegenerative disease [39] | Known | - | Unknown |
3 | miR-520d-5p | 12 | 130 | Black (8), Blue (14), Brown (21), Green (4), Greenyellow(1), Magenta (2), Pink (1), Purple (1), Red (8), Tan (1), Turquoise (52), Yellow (17). | Alzeimer’s disease [76] | Known | - | Unknown |
4 | miR-524-5p | 12 | 130 | Black (8), Blue (14), Brown (21), Green (4), Greenyellow(1), Magenta (2), Pink (1), Purple (1), Red (8), Tan (1), Turquoise (52), Yellow (17). | neuroblastoma [77] | Known | Amyotrophic lateral sclerosis [59]. | Known |
5 | miR-519b-5p | 12 | 109 | Black (4), Blue (19), Brown (10), Green (1), Lightcyan(1), Lightyellow(1), Magenta (3), Pink (1), Red (11), salmon(1), Turquoise (43), Yellow (14). | glioma [47] | Known | - | Unknown |
6 | miR-519a | 12 | 109 | Black (4), Blue (19), Brown (10), Green (1), Lightcyan(1), Lightyellow(1), Magenta (3), Pink (1), Red (11), salmon(1), Turquoise (43), Yellow (14). | down syndrome related AD [77] | Known | - | Unknown |
7 | miR-519c-3p | 12 | 109 | Black (4), Blue (19), Brown (10), Green (1), Lightcyan(1), Lightyellow(1), Magenta (3), Pink (1), Red (11), salmon(1), Turquoise (43), Yellow (14). | neuroblastoma [77] | Known | - | Unknown |
8 | miR-495 | 12 | 102 | Black (3), Blue (17), Brown (8), Green (7), Greenyellow(1), Lightcyan(1), Lightyellow(1), Magenta (2), purple(2), Red (8), Turquoise (40), Yellow (12). | HIV mediated dementia [39] | Known | Age mediated skeletal muscle contamination [54] | Known |
9 | miR-944 | 11 | 138 | Black (6), Blue (22), Brown (18), Green (3), Lightyellow(1), Magenta (1), Midnightblue(1), Purple(1), Red (11), Turquoise (57), Yellow (17). | Cancer metastasis in brain [70] | Known | - | Unknown |
10 | miR-664 | 11 | 123 | Black (10), Blue (17), Brown (9), Cyan(1), Green (6), Magenta (2), Purple(1), Red (13), Tan(1) Turquoise (46), Yellow (17). | Psychiatric and Neurodegenerative disease [44]. | Known | - | Unknown |