Table 7 List of eighteen detected color-modules of genes for the inter-species analysis of human and rhesus samples by the proposed method with related biologically and statistically information
Sl. No | Module color | Gene | Related major significant KEGG pathways (p-value) | Related major signifiacnt GO-terms (p-value) | miR (targeter) | TF (targeter) |
|---|---|---|---|---|---|---|
1 | Black | 65 | Alzeimer’s disease (8.41E-13), Neuro-trophin Signaling pathway (5.46E-6) | GO:CC:- GO:0014069 Postsynaptic Density (2.3E-2). | 66 | 25 |
| Â | Â | Â | Â | GO:MFs:- GO:0060589 zinc ion binding (1.7E-3), cytokine binding (0.00895). | Â | Â |
2 | Blue | 218 | Tight junction (1.1E-2), Phosphatidylinositol signaling system (2.0E-2) | GO:BPs:- GO:0035556 Intracellular signaling transduction (4.2E-4), GO:0000902 cell morphogenesis (2.7E-3) | 83 | 71 |
| Â | Â | Â | Â | GO:CCs:- GO:0014069 Synaptosome (4.7E-3), GO:0035097 histone methyl transferase complex (2.9E-2). | Â | Â |
3 | Brown | 167 | - | GO:BPs:-GO:0048666 Neuron development (2.2E-2), GO:0000902 cell morphogenesis (2.6E-2). | 53 | 59 |
| Â | Â | Â | Â | GO:CC:- intracellular organelle lumen (0.019554). | Â | Â |
| Â | Â | Â | Â | GO:MFs:- protein kinase activity (1.82E-08), protein serine/threonine kinase activity (4.33E-07), MAP kinase tyrosine/serine/threonine phosphatase activity (0.004947), protein tyrosine kinase activity (0.012018). | Â | Â |
4 | Cyan | 1 | - | - | 5 | 4 |
5 | Green | 63 | - | GO:CCs:- GO:0044459 plasma membrane part (2.8E-2), GO:0044431 golgi apparatus part (4.4E-2). | 27 | 9 |
6 | Greenyellow | 4 | - | - | 6 | 4 |
7 | Grey60 | 2 | - | - | 17 | 3 |
8 | Lightcyan | 2 | - | GO:BPs:- GO:0048754 branching morphogenesis of an epithelial tube (4.8E-3), GO:0001525 angiogenesis (1.1E-2).. | 14 | 1 |
9 | Lightyellow | 3 | B-cell receptor signaling pathway (2.9E-2), T cell receptor signaling pathway (4.2E-2). | GO:BPs:- negative regulation of transport (2.0E-2), regulation of cellular localization (3.6E-2). | 26 | 1 |
10 | Magenta | 16 | - | GO:CC:- GO:0045202 synapse (3.6E-2). | 3 | 6 |
11 | Midnightblue | 2 | - | - | 1 | 1 |
12 | Pink | 4 | - | GO:BP:- GO:0014070 response to organic cyclic substance (1.80E-2). | 3 | 0 |
13 | Purple | 9 | - | - | 0 | 5 |
14 | Red | 89 | - | - | 80 | 11 |
15 | Salmon | 1 | - | - | 44 | 2 |
16 | Tan | 2 | - | - | - | - |
17 | Turquoise | 451 | adherens junction (3.0E-2) | GO:BPs:- negative regulation of signal transduction (7.7E-3), negative regulation of cell communication (1.1E-2). GO:CCs:- neuron projection (3.4E-2). GO:MFs:- protein complex binding (6.3E-3), SMAD binding (1.3E-2), DNA binding (4.5E-2), enzyme binding (4.6E-2), ion binding (4.9E-2). | 250 | 130 |
18 | Yellow | 2 | MAPK signaling pathway (1.5E-2). | GO:BPs:- hindbrain morphogenesis (2.3E-2), hindbrain development (2.4E-2), Ras protein signal transduction (2.3E-2). GO:CCs:- cell junction (4.9E-5), synapse (2.4E-2), postsynaptic density (3.3E-2). GO:MFs:- GTPase regulator activity (2.1E-5), transcription factor binding (4.3E-2). | 62 | 82 |