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Table 7 List of eighteen detected color-modules of genes for the inter-species analysis of human and rhesus samples by the proposed method with related biologically and statistically information

From: Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus

Sl. No Module color Gene Related major significant KEGG pathways (p-value) Related major signifiacnt GO-terms (p-value) miR (targeter) TF (targeter)
1 Black 65 Alzeimer’s disease (8.41E-13), Neuro-trophin Signaling pathway (5.46E-6) GO:CC:- GO:0014069 Postsynaptic Density (2.3E-2). 66 25
     GO:MFs:- GO:0060589 zinc ion binding (1.7E-3), cytokine binding (0.00895).   
2 Blue 218 Tight junction (1.1E-2), Phosphatidylinositol signaling system (2.0E-2) GO:BPs:- GO:0035556 Intracellular signaling transduction (4.2E-4), GO:0000902 cell morphogenesis (2.7E-3) 83 71
     GO:CCs:- GO:0014069 Synaptosome (4.7E-3), GO:0035097 histone methyl transferase complex (2.9E-2).   
3 Brown 167 - GO:BPs:-GO:0048666 Neuron development (2.2E-2), GO:0000902 cell morphogenesis (2.6E-2). 53 59
     GO:CC:- intracellular organelle lumen (0.019554).   
     GO:MFs:- protein kinase activity (1.82E-08), protein serine/threonine kinase activity (4.33E-07), MAP kinase tyrosine/serine/threonine phosphatase activity (0.004947), protein tyrosine kinase activity (0.012018).   
4 Cyan 1 - - 5 4
5 Green 63 - GO:CCs:- GO:0044459 plasma membrane part (2.8E-2), GO:0044431 golgi apparatus part (4.4E-2). 27 9
6 Greenyellow 4 - - 6 4
7 Grey60 2 - - 17 3
8 Lightcyan 2 - GO:BPs:- GO:0048754 branching morphogenesis of an epithelial tube (4.8E-3), GO:0001525 angiogenesis (1.1E-2).. 14 1
9 Lightyellow 3 B-cell receptor signaling pathway (2.9E-2), T cell receptor signaling pathway (4.2E-2). GO:BPs:- negative regulation of transport (2.0E-2), regulation of cellular localization (3.6E-2). 26 1
10 Magenta 16 - GO:CC:- GO:0045202 synapse (3.6E-2). 3 6
11 Midnightblue 2 - - 1 1
12 Pink 4 - GO:BP:- GO:0014070 response to organic cyclic substance (1.80E-2). 3 0
13 Purple 9 - - 0 5
14 Red 89 - - 80 11
15 Salmon 1 - - 44 2
16 Tan 2 - - - -
17 Turquoise 451 adherens junction (3.0E-2) GO:BPs:- negative regulation of signal transduction (7.7E-3), negative regulation of cell communication (1.1E-2). GO:CCs:- neuron projection (3.4E-2). GO:MFs:- protein complex binding (6.3E-3), SMAD binding (1.3E-2), DNA binding (4.5E-2), enzyme binding (4.6E-2), ion binding (4.9E-2). 250 130
18 Yellow 2 MAPK signaling pathway (1.5E-2). GO:BPs:- hindbrain morphogenesis (2.3E-2), hindbrain development (2.4E-2), Ras protein signal transduction (2.3E-2). GO:CCs:- cell junction (4.9E-5), synapse (2.4E-2), postsynaptic density (3.3E-2). GO:MFs:- GTPase regulator activity (2.1E-5), transcription factor binding (4.3E-2). 62 82