Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus

Table 3 Top ten targeter TFs for Human (that are connected with maximum number of gene-modules and that regulate maximum number of genes from the connected gene-modules) with information of their maximum number of regulated genes as well as gene-modules, and verified information of them

SL. No	TFs	Number of connected gene-modules	Number of regulated genes	Name of the connected gene-modules (number of regulated genes in the modules)	Disease and Disease-verified information of TFs	Status of TFs
1	WHSC1	3	9	Blue (4), Brown (2), Turquoise (3).	wolf Hirschhorn syndrome [31]	Known
2	E2F4	3	7	Blue (4), Brown (2), Turquoise (1).	Neuro degeneration disorder [32]	Known
3	EPAS1	3	5	Blue (2), Brown (2), Turquoise (1).	Iron toxicity effected the aging of brain [33]	Known
4	LBX1	3	5	Blue (2), Brown (2), Turquoise (1).	Septo optic Dysplasia [73]	Known
5	MYST3	3	5	Blue (2), Brown (2), Turquoise (1).		Unknown
6	ZNF771	3	4	Blue (2), Brown (1), Turquoise (1).	-	Unknown
7	ZBTB16	3	3	Blue(1), Brown (1), Turquoise (1).	Hungtinton’s Disease [34]	Known
8	EZF1	3	3	Blue (1), Brown (1), Turquoise (1)	Parkinson’s Disease [35]	known
9	TRMT1	3	3	Blue (1), Brown (1), Turquoise (1).	Oxidative damage in Neurodegenrative diseases [36]	Known
10	SSRP1	3	3	Blue (1), Brown (1), Turquoise (1).	Alzheimer’s Disease [37]	Known

ISSN: 2730-6844