Skip to main content

Table 3 Top ten targeter TFs for Human (that are connected with maximum number of gene-modules and that regulate maximum number of genes from the connected gene-modules) with information of their maximum number of regulated genes as well as gene-modules, and verified information of them

From: Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus

SL. No TFs Number of connected gene-modules Number of regulated genes Name of the connected gene-modules (number of regulated genes in the modules) Disease and Disease-verified information of TFs Status of TFs
1 WHSC1 3 9 Blue (4), Brown (2), Turquoise (3). wolf Hirschhorn syndrome [31] Known
2 E2F4 3 7 Blue (4), Brown (2), Turquoise (1). Neuro degeneration disorder [32] Known
3 EPAS1 3 5 Blue (2), Brown (2), Turquoise (1). Iron toxicity effected the aging of brain [33] Known
4 LBX1 3 5 Blue (2), Brown (2), Turquoise (1). Septo optic Dysplasia [73] Known
5 MYST3 3 5 Blue (2), Brown (2), Turquoise (1).   Unknown
6 ZNF771 3 4 Blue (2), Brown (1), Turquoise (1). - Unknown
7 ZBTB16 3 3 Blue(1), Brown (1), Turquoise (1). Hungtinton’s Disease [34] Known
8 EZF1 3 3 Blue (1), Brown (1), Turquoise (1) Parkinson’s Disease [35] known
9 TRMT1 3 3 Blue (1), Brown (1), Turquoise (1). Oxidative damage in Neurodegenrative diseases [36] Known
10 SSRP1 3 3 Blue (1), Brown (1), Turquoise (1). Alzheimer’s Disease [37] Known