Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus

Table 1 List of five detected color-modules of genes for the intra-species analysis of human samples by the proposed method with related biologically and statistically information and related disease identification

Sl. No	Module color	Gene	Related major significant KEGG pathways (p-value) (diseases)	Related major signifiacnt GO-terms (p-value) (diseases)	miR (targeter)	TF (targeter)
1	Blue	102	-	-	276	56
2	Brown	98	Cell adhesion molecules (4.0E-2) [72] (Neuro disease [61]).	GO:CC:- GO:0005886 plasma membrane (1.0E-2) GO:MFs:- GO:0003774 motor activity (3.0E-2), (motor neuron degeneration [62]), GO:0003700 transcription factor activity (4.1E-2) (Hungtington’s Disease [63])	78	36
3	Green	3	-	-	31	2
4	Turquoise	121	-	GO:BP:- GO:0051252 regulation of RNA metabolic process (1.7E-3). GO:MFs:- GO:0003677 DNA binding (2.4E-3), GO:0003700 transcription factor activity (2.7E-2).	112	40
5	Yellow	8	mTOR signaling pathway (0.032929).	-

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