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Table 4 Associations of the four significant SNPs in PDGFRB and MARCH1 with semen production traits in Chinese Holstein bulls (LSM ± SE)

From: Genetic effects of PDGFRB and MARCH1 identified in GWAS revealing strong associations with semen production traits in Chinese Holstein bulls

Genes

SNPs

Genotypes (no.)

SVPE (ml)

SMOT (%)

SCPE (×108/ml)

NSPE (×108)

NMSPE (×108)

PDGFRB

rs110305039

GG (269)

0.243 ± 0.159A

0.676 ± 0.739

0.054 ± 0.256

3.030 ± 2.440a

2.400 ± 1.811a

GT (359)

0.028 ± 0.138A

0.379 ± 0.962

−0.238 ± 0.222

−0.520 ± 2.112ab

−0.229 ± 1.568ab

TT (81)

−0.830 ± 0.289B

0.774 ± 0.871

−0.627 ± 0.467

−11.124 ± 4.447b

−8.184 ± 3.301b

p-value

0.0052**

0.6581

0.4034

0.0206*

0.0195*

  

%Var

11.67

  

7.92

9.97

MARCH1

rs211260176

CC (131)

−0.342 ± 0.228a

0.845 ± 1.019

−0.184 ± 0.367

−3.837 ± 3.496

−2.844 ± 2.595

CT (349)

−0.060 ± 0.140ab

0.678 ± 0.625

−0.296 ± 0.225

−1.493 ± 2.142

−0.847 ± 1.590

TT (231)

0.354 ± 0.171b

0.606 ± 0.766

−0.029 ± 0.276

3.301 ± 2.628

2.519 ± 1.951

p-value

0.0361*

0.3588

0.7537

0.2014

0.2083

 

%Var

5.19

    

rs208093284

CC (126)

−0.337 ± 0.232a

−0.881 ± 1.039

−0.129 ± 0.374

−3.481 ± 3.565

−2.576 ± 2.646

CT (311)

−0.124 ± 0.148ab

−0.857 ± 0.662

−0.323 ± 0.238

−2.211 ± 2.269

−1.368 ± 1.684

TT (270)

0.342 ± 0.158b

0.623 ± 0.709

−0.133 ± 0.256

2.619 ± 2.434

2.041 ± 1.806

p-value

0.0246*

0.2578

0.8348

0.2342

0.2445

 

%Var

4.84

    

rs43445726

CC (27)

−1.039 ± 0.501A

−2.929 ± 2.245

−0.446 ± 0.808

−11.113 ± 7.700ab

−8.185 ± 5.716

CT (225)

−0.499 ± 0.175A

−1.344 ± 0.785

−0.316 ± 0.283

−5.583 ± 2.691a

−4.037 ± 1.998

TT (471)

0.296 ± 0.122B

0.287 ± 0.546

−0.123 ± 0.197

2.384 ± 1.872b

1.929 ± 1.389

p-value

0.0001**

0.1179

0.8128

0.0203*

0.0189*

  

%Var

12.22

  

4.87

6.16

  1. P-value is the significance level from analyses of the association of SNPs with semen production traits. **: P < 0.01; *: P < 0.05. Different superscript letters (lower-case letters: P < 0.05; upper-case letters: P < 0.01; Bonferroni-adjusted value after multiple testing) refer to significant differences among the genotypes. %Var indicates the percentage of genetic variance explained by the significant SNPs for traits